Results 101 to 110 of about 18,661,987 (346)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Specific antigen/antibody interactions measured by force microscopy [PDF]

, 1996
Dammer U, Hegner M, Anselmetti D, et al. Specific antigen/antibody interactions measured by force microscopy. Biophysical journal. 1996;70(5):2437-2441.Molecular recognition between biotinylated bovine serum albumin and polyclonal, biotin-directed IgG ...
Dammer, Ulrich, H.J. Güntherodt, Wagner, Peter, U. Dammer, M. Dreier, D. Anselmetti, Hegner, Martin, Huber, Walter, Güntherodt, Hans-Joachim, W. Huber, Dreier, Markus, P. Wagner, Anselmetti, Dario ; https://orcid.org/, M. Hegner, Huber W, Dreier M, Güntherodt HJ, Dammer U, Wagner P, Hegner M, Anselmetti D   +20 more
core   +1 more source

UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes

Frontiers in Genetics, 2018
Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation, delimitation of these regions with high accuracy is ...
Santiago Radío, Santiago Radío, Rafael Sebastián Fort, Rafael Sebastián Fort, Beatriz Garat, José Sotelo-Silveira, José Sotelo-Silveira, Pablo Smircich, Pablo Smircich   +8 more
doaj   +1 more source

Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions

BMC Biology, 2023
Background Shifts in dynamic equilibria of the abundance of cellular molecules in plant-pathogen interactions need further exploration. We induced PTI in optimally growing Arabidopsis thaliana seedlings for 16 h, returning them to growth conditions for ...
Mohammad Abukhalaf, Carsten Proksch, Domenika Thieme, Jörg Ziegler, Wolfgang Hoehenwarter   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Molecular torsion balances for quantifying non-covalent interactions [PDF]

, 2013
Non-covalent interactions underpin the whole of chemistry and biology, but their study is extremely difficult in complicated biological systems. This thesis presents the application of synthetic molecular balances for gaining fundamental insights into ...
Mati, Ioulia
core  

Membrane interactions of S100A12 (Calgranulin C) [PDF]

, 2013
S100A12 (Calgranulin C) is a small acidic calcium-binding peripheral membrane protein with two EF-hand structural motifs. It is expressed in macrophages and lymphocytes and highly up-regulated in several human inflammatory diseases.
Costa-Filho, A.J., Wallace, Bonnie A., Araujo, A.P.U., Hofmann, A., Garcia, A.F., Lopes, J.L.S.   +5 more
core   +3 more sources

CyMIRA: The Cytonuclear Molecular Interactions Reference for Arabidopsis

bioRxiv, 2019
The function and evolution of eukaryotic cells depends upon direct molecular interactions between gene products encoded in nuclear and cytoplasmic genomes.
Evan S. Forsythe, Joel Sharbrough, Justin C. Havird, J. Warren, Daniel B. Sloan   +4 more
semanticscholar   +1 more source