Results 131 to 140 of about 6,135 (208)

Redox‐Tuned Oxycarbamates Enable Divergent C─N and C─C Functionalization of Indolizines Under Photoredox Catalysis With Green Light

Chemistry – A European Journal, EarlyView.
Nonafluoromesitylsulfonyl (Nms)‐substituted oxycarbamates are introduced as redox‐lowered radical precursors for green‐light photoredox synthesis. Selective N─O bond cleavage generates amidyl radicals that directly aminate indolizines in DMF, whereas DMSO promotes 1,2‐hydrogen atom transfer (HAT) to α‐amino carbon‐centered radicals and C─C bond ...
Kevin Klaus Stefanoni, René Wilhelm
wiley   +1 more source

Layer-selective hydrogenation and proton transport in twisted bilayer graphene. [PDF]

Nat Commun
Tong J, Chen G, Li H, Hoenig E, Alhashmi M, Zhang X, Bahamon D, Tainton GR, Sullivan-Allsop S, Mayamei Y, R da Costa D, Vega LF, Haigh SJ, Domaretskiy D, Peeters FM, Lozada-Hidalgo M.   +15 more
europepmc   +1 more source

Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke, Boitumelo Semete‐Makokotlela, Varnika Singh, Khanyisile Nkuku, Madelein Terblanche, Ezekiel T Mukanga, Nancy Ngum, Kudakwashe Dandajena, McNeil Chimus Mhango, Paulyne Wairimu, John Mwangi, Dominique Lagrave, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes. [PDF]

Nat Commun
Zhang Y, Li B, Liu X, Zheng X, Liu S, Nie G, Yang J, Ke Y, Li S, Zhang C.   +9 more
europepmc   +1 more source

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

Cannabinoid GPCRs, ectopic olfactory GPCRs and TRP channels: a prespecified baseline-edit-rescue framework for testing higher-order membrane-conditioned integration. [PDF]

Biol Methods Protoc
Yarar E.
europepmc   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

Development of a multifunctional nucleic acid response platform utilizing the Cas12a and Cas13a integrated targeting system. [PDF]

Nucleic Acids Res
Zhou J, Liu W, Nie X, Wang X, Hu Y, Wan C, Liao Y, Pan S.   +7 more
europepmc   +1 more source

Photoreversible Polyurea Actuators With Spatiotemporal Control and Adaptive Mechanics

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A light–thermal responsive polyurea network incorporating reversibly dimerizable anthracene units enables spatiotemporal modulation of cross‐linking density and nearly 400‐fold stiffness tuning. Integrating programmable anisotropy, photopatterning, self‐healing, and photowelding within a single framework, this bioinspired “one network–multifunction ...
Zhiwen Song, Wang Li, Xinru Guo, Rui Pu, Wenxin Wang, Yujun Cheng, Liang Shen, Fei Gao   +7 more
wiley   +1 more source

Synthetic promoter design in plants: integration of computational and experimental approaches. [PDF]

Front Plant Sci
Yaschenko AE, Alonso JM, Stepanova AN.
europepmc   +1 more source