Chemistry – A European Journal, EarlyView.The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik +3 more
wiley +1 more source
Reset-free DNA logic circuits for real-time input processing and memory. [PDF]
Sci AdvSim J +8 more
europepmc +1 more source
Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality
Chemistry – A European Journal, EarlyView.Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim +3 more
wiley +1 more source
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, EarlyView.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source
Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle
Chemistry – A European Journal, EarlyView.Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou +4 more
wiley +1 more source
Enzyme-driven triplex structure-based DNA logic circuits. [PDF]
J NanobiotechnologyLiu X +14 more
europepmc +1 more source
Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening
Clinical Pharmacology &Therapeutics, EarlyView.Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke +12 more
wiley +1 more source
Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications. [PDF]
Chem SciHu Y +5 more
europepmc +1 more source
Photoreversible Polyurea Actuators With Spatiotemporal Control and Adaptive Mechanics
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.A light–thermal responsive polyurea network incorporating reversibly dimerizable anthracene units enables spatiotemporal modulation of cross‐linking density and nearly 400‐fold stiffness tuning. Integrating programmable anisotropy, photopatterning, self‐healing, and photowelding within a single framework, this bioinspired “one network–multifunction ...
Zhiwen Song +7 more
wiley +1 more source
RATEX: A Scalable RNA-Based Platform for Logical and Multi-Layered Cellular Programming. [PDF]
Angew Chem Int Ed EnglGoh H, Kang H, Kim C, Kim J.
europepmc +1 more source