Results 51 to 60 of about 1,944,612 (362)

Molecular detection of parasites (Trematoda, Digenea: Bucephalidae and Monorchiidae) in the European flat oyster Ostrea edulis (Mollusca: Bivalvia) [PDF]

, 2018
Members of the globally distributed bivalve family Ostreidae (oysters) have a significant role in marine ecosystems and include species of high economic importance. In this work, we report the occurrence of digenean parasites of the families Bucephalidae
Cervelli, M., Di Giulio, A., Furfaro, G., Mancini, E., Mariottini, P., Oliverio, M., Salvi, D.   +6 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone [PDF]

, 2016
Background: Evolutionary processes, including selection and differential fitness, shape the introgression of genetic material across a hybrid zone, resulting in the exchange of some genes but not others.
Kovach, Adrienne I., Olsen, Brian J., Shriver, W. Gregory, Walsh, Jennifer   +3 more
core   +4 more sources

Identification of a new allele of the Dw gene causing brachytic dwarfing in peach

BMC Research Notes, 2018
Objective Peach brachytic dwarfism determined by Dwarf gene (Dw) is an undesired trait segregating in some peach breeding programs. Recently, a single nucleotide polymorphism (SNP) mutation in the gibberellin insensitive dwarf 1 (GID1) peach gene causing
Celia M. Cantín, Pere Arús, Iban Eduardo   +2 more
doaj   +1 more source

1RS TRANSLOCATION IN CROATIAN WINTER WHEAT VARIETIES [PDF]

Poljoprivreda, 2015
The translocation between the short arm of chromosome 1R of rye and the long arm of chromosome 1A, 1B or 1D of wheat represents practically the most common introduced foreign genes into the genome of hexaploid wheat.
Sunčica Guberac, Sonja Petrović, Vlado Guberac, Sonja Marić   +3 more
doaj   +1 more source

Distribution of genetic diversity in wild European populations of prickly lettuce (Lactuca serriola): implications for plant genetic resources management [PDF]

, 2010
Genetic variation in Lactuca serriola, the closest wild relative of cultivated lettuce, was studied across Europe from the Czech Republic to the United Kingdom, using three molecular marker systems, simple sequence repeat (SSR, microsatellites), AFLP and
Dehmer, K.J., Hintum, T.J.L., van, Linden, C.G., van der, Sretenovic Rajicic, T., Treuren, R., van, Wiel, C.C.M., van de   +5 more
core   +2 more sources

Molecular markers of paragangliomas/pheochromocytomas

Oncotarget, 2017
Paragangliomas/pheochromocytomas comprise rare tumors that arise from the extra-adrenal paraganglia, with an incidence of about 2 to 8 per million people each year. Approximately 40% of cases are due to genetic mutations in at least one out of more than 30 causative genes. About 25-30% of pheochromocytomas/paragangliomas develop under the conditions of
Dmitry V. Kalinin, Alexey A. Dmitriev, Andrew R. Zaretsky, Boris Alekseev, O. A. Stepanov, Anna V. Kudryavtseva, George S. Krasnov, Svetlana Zhikrivetskaya, Anastasiya V. Snezhkina, Alexey Moskalev, Nataliya V. Melnikova, Anatoly V. Pokrovsky, Alexander L. Golovyuk   +12 more
openaire   +4 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source