Results 91 to 100 of about 6,997,513 (404)

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

open access: yesFEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti   +2 more
wiley   +1 more source

Molecular markers for colorectal cancer screening

open access: yesGut, 2015
Colorectal cancer (CRC), although a significant cause of morbidity and mortality worldwide, has seen a declining incidence and mortality in countries with programmatic screening.
B. Dickinson   +3 more
semanticscholar   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

open access: yesFEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka   +6 more
wiley   +1 more source

In-situ Formation of Amorphous Co-Al-P Layer on CoAl Layered Double Hydroxide Nanoarray as Neutral Electrocatalysts for Hydrogen Evolution Reaction

open access: yesFrontiers in Chemistry, 2020
Exploration of high-efficiency and inexpensive electrode catalysts is of vital importance for the hydrogen evolution reaction (HER). In this research, an amorphous Co-Al-P layer was constructed on the surface of CoAl layered double hydroxide (CoAl-LDH ...
Wanqing Teng   +6 more
doaj   +1 more source

Relevant molecular markers and targets [PDF]

open access: yesGynecologic Oncology, 2006
Ovarian cancer is a heterogeneous disease with extensive cytogenetic and molecular heterogeneity including aneuploidy, chromosomal alterations, mutations and overexpression as well as a natural propensity to disseminate and spread, making it difficult to diagnose at an early stage. Insights into the molecular mechanisms operative in cancer development,
Kathleen M. Darcy, Russell J. Schilder
openaire   +3 more sources

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

open access: yesFEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten   +10 more
wiley   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Epigenetic factors and molecular markers of the risk of early pregnancy losses [PDF]

open access: yesГинекология, 2019
Background. Miscarriage is a common complication in early pregnancy. Current studies have shown a higher prevalence of miscarriage, ranging from 10 to 20%.
Nataly I Frolova   +1 more
doaj   +1 more source

Comparison of molecular markers to detect fresh sewage in environmental waters [PDF]

open access: yes, 2009
Human-specific Bacteroides HF183 (HS-HF183), human-specific Enterococci faecium esp (HS-esp), human-specific adenoviruses (HS-AVs) and human-specific polyomaviruses (HS-PVs) assays were evaluated in freshwater, seawater and distilled water to detect ...
Ahmed, Warish   +4 more
core   +2 more sources

Tomato Molecular Markers

open access: yesJournal of Fruit and Ornamental Plant Research, 2011
Tomato Molecular Markers Tomato (Solanum lycopersicum L.) is one of the most popular vegetable grown in many regions of the world. Due to its high taste quality and nutritional value increase interest in the cultivation of this species and its consumption.
Mirosława Staniaszek   +2 more
openaire   +2 more sources

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