Results 111 to 120 of about 2,144,828 (297)

A Genetic Linkage Map Using an F1 Population in Rubber Tree (Hevea brasiliensis) based on microsatellite markers. P0527 [PDF]

, 2012
The construction of molecular gene linkage map in Hevea requires specific methodology because of high heterozygosity. Unlike annual crops, a cross between two heterozygous parents in Hevea can yield information up to four alleles, which are segregated ...
Garcia, Antonio Augusto Franco, Garcia, Dominique, Gazaffi, Rodrigo, Le Guen, Vincent, Mantello, Camilia Campos, Souza, Anete Pereira, Souza, Livia Moura, Suzuki, Fernando   +7 more
core  

Principal molecular markers

, 2021
Molecular markers are molecular phenotypes originating from any expressed or unexpressed segments of DNA that come from genetic inheritance and lend themselves to the differentiation of one or more individuals. It can be classified into two groups: the first, markers are obtained by hybridization and the second, markers are obtained by DNA ...
Oliveira, Altacis Junior, Oliveira, Taniele Carvalho de, Santos, Andressa Alves Cabreira dos, Siqueira, Thalyson Ade, Duarte, Willian Martins, Caldeira, Daniela Soares Alves, Vilarinho, Marcella Karoline Cardoso, Almici, Mirian da Silva, Silva, Gustavo Ferreira da, Barelli, Marco Antonio Aparecido, Karsburg, Isane Vera   +10 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Multi-dimensional integration of gene expression, protein evidence, and serum autoantibodies for diagnostic modeling in esophageal squamous cell carcinoma

Frontiers in Immunology
IntroductionEsophageal squamous cell carcinoma (ESCC) accounts for most esophageal cancer cases. This study implemented a multi-dimensional integrative approach to identify tumor-associated autoantibodies (TAAbs) and develop a diagnostic model for the ...
Yuanlin Zou, Yuanlin Zou, Han Wang, Han Wang, Han Wang, Caijuan Song, Sirun Wang, Tiandong Li, Yifan Cheng, Yifan Cheng, Yifan Cheng, Hua Ye, Hua Ye, Hua Ye, Jianxiang Shi, Jianxiang Shi, Jianxiang Shi, Keyan Wang, Keyan Wang, Keyan Wang, Kaijuan Wang, Kaijuan Wang, Kaijuan Wang, Chunhua Song, Chunhua Song, Chunhua Song, Peng Wang, Peng Wang, Peng Wang, Jicun Zhu   +29 more
doaj   +1 more source

Therapeutic Efficacy of Sulfadoxine-Pyrimethamine and Prevalence of Resistance Markers in Tanzania Prior to Revision of Malaria Treatment Policy: Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Mutations in Monitoring in Vivo Resistance. [PDF]

, 2004
Prior to the 2001 malarial treatment policy change in Tanzania, we conducted trials to assess the efficacy of sulfadoxine-pyrimethamine (SP) and the usefulness of molecular markers in monitoring resistance.
Abdulla, Salim, Beck, Hans-Peter, Kataraihya, Johannes, Lemnge, Martha, Malisa, Allen, Mshinda, Hassan, Mugittu, Kefas, Mwita, Alex, Ndejembi, Modesta, Nkya, Watoky, Premji, Zulfikar   +10 more
core   +1 more source

Molecular marker v1

, 2019
SSR and SRAP markers were employed to assess the genetic diversity and structure of sixty-four samples from four populations ofEmmenopterys henryi. Twelve pairs of SRAP primers generated 86 bands, and polymorphism rate was 88.37%. 148 polymorphic alleles were detected by ten pairs of SSR primers, with an average number of polymorphic alleles per primer
Yanli Niu, Yansong Peng, Wenxing Chen, Wenxing Chen, Sadaruddin Chachar, Pingxian Zhang, Saixia Zhou, Yuan Gao   +7 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The review of recent advances in fish genetics and biotechnology [PDF]

, 2012
Great advances have been, and are being made in our knowledge of the genetics and molecular biology (including genomics, proteomics and structural biology).
Mgbabu , Christopher Nwokwa
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source