Results 91 to 100 of about 5,285,990 (293)

Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis

Frontiers in Oncology
PurposeThrough a pilot study, we performed whole gut metagenomic analysis in 17 Lynch syndrome (LS) families, including colorectal cancer (CRC) patients and their healthy first-degree relatives.
Mohammad Sadeghi, Denis Mestivier, Etienne Carbonnelle, Robert Benamouzig, Khashayarsha Khazaie, Iradj Sobhani, Iradj Sobhani   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A fast and cost-effective approach to develop and map EST-SSR markers: oak as a case study [PDF]

, 2010
Background: Expressed Sequence Tags (ESTs) are a source of simple sequence repeats (SSRs) that can be used to develop molecular markers for genetic studies.
Ikaran, Ziortza, Mattioni, Claudia, Herrán, A., Chancerel, Emilie, Fiorella Villani, Antoine de Daruvar, Ueno, Saneyoshi, FRIGERIO, Jean-Marc, Catherine Bodénès, Marcello Cherubini, Guichoux, E., GOICOECHEA, Pablo G, Claudia Mattioni, Frigerio, J.M., Buonamici, Anna, Plomion, Christophe, Emilie Chancerel, Hans-Peter Koelewijn, KOELEWIJN, Hans-Peter, de Daruvar, A., Bodénès, Catherine, Villani, F., Saneyoshi Ueno, Chancerel, E., Villani, Fiorella, Cherubini, M., Durand, Jérôme, DUMOULIN, Pierre-Yves, Buonamici, A., Sebastiani, F., Dumoulin, Pierre Yves, Vendramin, Giovanni, Cherubini, Marcello, Alberto, Florian, de Daruvar, Antoine, Ana Herrán, Koelewijn, H.P., Ziortza Ikaran, Cabané, C., Alberto, F., Cyril Cabané, Pablo G Goicoechea, Koelewijn, Hans Peter, Jérôme Durand, Giovanni Vendramin, Sebastiani, Federico, Goicoechea, P.G., Kremer, A., Florian Alberto, Gailing, Oliver, Dumoulin, P.Y., Anna Buonamici, Guichoux, Erwan, Goicoechea, Pablo G., Ueno, S., Herrán, Ana, Vendramin, Giovanni G., Ikaran, Z., Vendramin, G., Daruvar, A., de, Christophe Plomion, Durand, Jérôme, J., Pierre-Yves Dumoulin, Gailing, O., Jean-Marc Frigerio, Oliver Gailing, Erwan Guichoux, Bodénès, C., Federico Sebastiani, Kremer, Antoine, Mattioni, C., Plomion, C., Antoine Kremer, Cabané, Cyril, Durand, J., Frigerio, Jean Marc   +75 more
core   +1 more source

In-situ Formation of Amorphous Co-Al-P Layer on CoAl Layered Double Hydroxide Nanoarray as Neutral Electrocatalysts for Hydrogen Evolution Reaction

Frontiers in Chemistry, 2020
Exploration of high-efficiency and inexpensive electrode catalysts is of vital importance for the hydrogen evolution reaction (HER). In this research, an amorphous Co-Al-P layer was constructed on the surface of CoAl layered double hydroxide (CoAl-LDH ...
Wanqing Teng, Zhaomei Sun, Zhaomei Sun, Junfeng Xie, Ziqiang Wang, Xiangjiang Zheng, Bo Tang   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Molecular Markers in Plants

, 2013
Molecular Markers in Plants surveys an array of technologies used in the molecular analysis of plants. The role molecular markers play in plant improvement has grown significantly as DNA sequencing and high-throughput technologies have matured.
Henry, Robert J.
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source