Results 1 to 10 of about 4,145,178 (349)

CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators

Molecules, 2022
Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed ...
Zeqi Shi, Zuowen He, Dao Wen Wang
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Ectoine Production Using Novel Heterologous EctABC_{S. salarius} from Marine Bacterium Salinicola salarius

Applied Sciences, 2021
Ectoine, a heterocyclic amino acid produced by various bacteria, was widely used in the fields of cosmetics and medicine. In this study, a novel ectoine synthesis cluster from marine bacterium Salinicola salarius 1A01339 was firstly introduced into ...
Yue Su, Wenting Peng, Tong Wang, Yanhui Li, Luyu Zhao, Xinyu Wang, Ying Li, Ling Lin   +7 more
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Enantioselectivity of discretized helical supramolecule consisting of achiral cobalt phthalocyanines via chiral-induced spin selectivity effect

Nature Communications, 2023
Enantioselectivity of helical aggregation is conventionally directed either by its homochiral ingredients or by introduction of chiral catalysis. The fundamental question, then, is whether helical aggregation that consists only of achiral components can ...
Hiroki Aizawa, Takuro Sato, Saori Maki-Yonekura, Koji Yonekura, Kiyofumi Takaba, Tasuku Hamaguchi, Taketoshi Minato, Hiroshi M. Yamamoto   +7 more
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Genomic and phenotypic biology of a novel Dickeya zeae WH1 isolated from rice in China: Insights into pathogenicity and virulence factors

Frontiers in Microbiology, 2022
Soft rot caused by Dickeya zeae is an important bacterial disease affecting rice and other plants worldwide. In this study, Nanopore and Illumina sequencing platforms were used to sequence the high-quality complete genome of a novel D.
Xiao-Juan Tan, Zhi-Wei Zhang, Jing-Jing Xiao, Wei Wang, Feng He, Xuan Gao, Bin Jiang, Liang Shen, Xu Wang, Yang Sun, Guo-Ping Zhu   +10 more
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Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population

Genes and Environment, 2021
Background Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases.
Yonghui Yang, Dandan Li, Chunjuan He, Linna Peng, Shishi Xing, Mei Bai, Hao Rong, Dongya Yuan, Yongjun He, Xue He, Li Wang, Tianbo Jin   +11 more
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Hypoxia is fine-tuned by Hif-1α and regulates mesendoderm differentiation through the Wnt/β-Catenin pathway

BMC Biology, 2022
Background Hypoxia naturally happens in embryogenesis and thus serves as an important environmental factor affecting embryo development. Hif-1α, an essential hypoxia response factor, was mostly considered to mediate or synergistically regulate the effect
Xiaopeng Shen, Meng Li, Chunguang Wang, Zhongxian Liu, Kun Wu, Ao Wang, Chao Bi, Shan Lu, Hongan Long, Guoping Zhu   +9 more
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Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress

Microbiology Spectrum, 2023
Among various environmental stresses, the depletion of inorganic phosphate, which is an important signaling molecule that modulates virulence production, is notable. In our previous study, we demonstrated that lapA, encoding alkaline phosphatase, plays a
Xiaojuan Tan, Xi Cheng, Jingjing Xiao, Qianqian Liu, Dongsheng Du, Minghui Li, Yang Sun, Jinwei Zhou, Guoping Zhu   +8 more
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A Unified Mechanism on the Formation of Acenes, Helicenes, and Phenacenes in the Gas Phase. [PDF]

, 2020
A unified low-temperature reaction mechanism on the formation of acenes, phenacenes, and helicenes-polycyclic aromatic hydrocarbons (PAHs) that are distinct via the linear, zigzag, and ortho-condensed arrangements of fused benzene rings-is revealed. This
Ablikim, Utuq, Ahmed, Musahid, Azyazov, Valeriy N, Bashkirov, Eugene K, Evseev, Mikhail M, Kaiser, Ralf I, Mebel, Alexander M, Xu, Bo, Zhao, Long   +8 more
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Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

AMB Express, 2021
Bacterial biofilms formation is one of the major reasons for treatment failure in chronic wound infections. Therefore, diagnostic biomarkers remain the best option for prevention and treatment of chronic wound infections by biofilms.
Xiaojuan Tan, Xi Cheng, Mei Hu, Yifan Zhang, Aiqun Jia, Jinwei Zhou, Guoping Zhu   +6 more
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The role of pharmacology in anticancer drug development

ADMET and DMPK, 2018
Drug development consists of many sequential and parallel steps; failure in one of the steps can lead to discontinuation of the process. The process is time-consuming and very expensive, especially the clinical phase.
Godefridus J. Peters, Anne-Sophie Govaerts, Hans R. Hendriks, for EORTC Pharmacology and Molecular Mechanism Group   +3 more
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