Results 221 to 230 of about 14,308,960 (385)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Molecular Mechanisms of Lymphangiogenesis [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2002
Kari Alitalo, Taija Makinen
openaire   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Cancer pain: molecular mechanisms and management. [PDF]

Mol Biomed
Wang WL, Hao YH, Pang X, Tang YL.
europepmc   +1 more source

Molecular mechanisms of DNA repair defects and heterogeneity in xeroderma pigmentosum [PDF]

, 1977
Hiraku Takebe
openalex   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Molecular mechanisms underlying leaf enlargement in spaceflight-mutated 'Deqin'alfalfa. [PDF]

BMC Genomics
Kuang Q, Ding R, Huang D, He C, Jiang H.
europepmc   +1 more source

Molecular mechanisms of toxin damage [PDF]

, 1978
Hilary J. Rogers
openalex   +1 more source

Cellular and Molecular Mechanisms of Pain

Cell, 2009
A. Basbaum, D. Bautista, G. Scherrer, D. Julius   +3 more
semanticscholar   +1 more source

Cellular and molecular mechanisms of allergic asthma.

Molecular Aspects of Medicine, 2021
Z. Komlósi, W. van de Veen, Nóra Kovács, G. Szűcs, M. Sokolowska, L. O’Mahony, M. Akdiş, C. Akdis   +7 more
semanticscholar   +1 more source