Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway
iScienceSummary: Type I interferon (IFN) production is crucial in tuberculosis pathogenesis, yet the bacterial factors initiating this process are incompletely understood. CpsA, protein of Mycobacterium marinum and Mycobacterium tuberculosis, plays a key role in
Yue Ding +18 more
doaj +1 more source
Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria [PDF]
, 2017 Host immune and physical barriers protect against pathogens but also impede the establishment of essential symbiotic partnerships. To reveal mechanisms by which beneficial organisms adapt to circumvent host defenses, we experimentally evolved ...
Cooper, Vaughn S. +8 more
core +3 more sources
Consumed by Abdominal Distention
Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge +3 more
wiley +1 more source
Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings
Advanced Materials, EarlyView.Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed +9 more
wiley +1 more source
Approaches for in silico finishing of microbial genome sequences
Genetics and Molecular BiologyThe introduction of next-generation sequencing (NGS) had a significant effect on the availability of genomic information, leading to an increase in the number of sequenced genomes from a large spectrum of organisms.
Frederico Schmitt Kremer +2 more
doaj +1 more source
Pim1 Impacts Enterovirus A71 Replication and Represents a Potential Target in Antiviral Therapy
iScience, 2019 Summary: Enterovirus A71 (EV-A71) infection causes hand-foot-and-mouth disease (HFMD) and fatal neurological diseases, and there are no effective treatments.
Fanghang Zhou +5 more
doaj +1 more source
Molecular biology techniques as a tool for detection and characterisation of Mycobacterium avium subsp. paratuberculosis [PDF]
, 2002 Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the causative agent of paratuberculosis, also known as Johne’s disease, a chronic intestinal infection in cattle and other ruminants.
Englund, Stina
core
Advanced Materials, EarlyView.ABSTRACT Biohybrid microswimmers, which integrate the unique mobility and taxis of living cells with the versatility of synthetic cargo, offer exciting opportunities for targeted delivery. However, current biohybrids lack autonomous decision‐making capabilities due to the absence of communication between living and synthetic components. Here, we report
Xiaoran Zheng +3 more
wiley +1 more source
Historical perspective and importance of microbiology in modern era
Environment Conservation Journal, 2013 This paper introduces the historical view of microbiology and discuss the importance of microorganisms not only as causative agents of disease but also as important contributors to food production, antibiotic manufacture, vaccine development, and ...
Anjali Sethi , Molly Madan
doaj +1 more source