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Molecular Mimicry and Uveitis [PDF]

Frontiers in Immunology, 2020
Molecular or antigenic mimicry is a term for the similarity of different antigens, which can be confused by the immune system. Antigen recognition by antibodies and T cell receptors is specific, but not restricted to a single antigen.
Gerhild Wildner, Maria Diedrichs-Möhring   +1 more
doaj   +5 more sources

Molecular mimicry and cancer vaccine development

Molecular Cancer, 2023
Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro   +6 more
doaj   +5 more sources

Microbiome, Parkinson’s Disease and Molecular Mimicry [PDF]

Cells, 2019
Parkinson’s Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external ...
Fabiana Miraglia, Emanuela Colla
doaj   +4 more sources

Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins

Viruses, 2022
Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic
Janelle Nunez-Castilla, Vitalii Stebliankin, Prabin Baral, Christian A. Balbin, Masrur Sobhan, Trevor Cickovski, Ananda Mohan Mondal, Giri Narasimhan, Prem Chapagain, Kalai Mathee, Jessica Siltberg-Liberles   +10 more
doaj   +2 more sources

Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity

Microorganisms, 2023
The concept of molecular mimicry describes situations in which antigen sharing between parasites and hosts could benefit pathogen evasion from host immune responses.
Yuri Chaves Martins, Arnon Dias Jurberg, Cláudio Tadeu Daniel-Ribeiro   +2 more
doaj   +2 more sources

Potential clinical implications of molecular mimicry‐induced autoimmunity

Immunity, Inflammation and Disease
Background Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self‐antigens, which can activate cross‐reactive lymphocytes that attack ...
Bandar A Suliman
doaj   +2 more sources

Molecular mimicry as a mechanism of viral immune evasion and autoimmunity

Nature Communications
Mimicry of host protein structures, or ‘molecular mimicry’, is a common mechanism employed by viruses to evade the host’s immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the
Cole Maguire, Chumeng Wang, Akshara Ramasamy, Cara Fonken, Brinkley Morse, Nathan Lopez, Dennis Wylie, Esther Melamed   +7 more
doaj   +2 more sources

Molecular mimicry and autoimmunity.

Journal of Autoimmunity, 2018
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual.
M. Rojas, Paula Restrepo-Jiménez, D. Monsalve, Y. Pacheco, Y. Acosta-Ampudia, C. Ramírez-Santana, P. Leung, A. Ansari, M. Gershwin, J. Anaya   +9 more
semanticscholar   +4 more sources

Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella

mBio, 2020
Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves.
Sonia Mondino, Silke Schmidt, Carmen Buchrieser   +2 more
doaj   +2 more sources

Molecular Mimicry in Multiple Sclerosis

, 2007
One of the most common demyelinating central nervous system (CNS) diseases in humans is multiple sclerosis (MS). The disease can be very debilitating with vision loss, motor and sensory disturbances, and cognitive impairment. The clinical course may present as a relapsing-remitting disease course, a progressive disease course, or a combination thereof.
Jane E. Libbey, Lori McCoy, Robert S. Fujinami   +2 more
openalex   +4 more sources