Molecular mimicry as a mechanism of viral immune evasion and autoimmunity [PDF]
Nature CommunicationsMimicry of host protein structures, or ‘molecular mimicry’, is a common mechanism employed by viruses to evade the host’s immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the
Cole Maguire +7 more
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Potential clinical implications of molecular mimicry‐induced autoimmunity [PDF]
Immunity, Inflammation and DiseaseBackground Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self‐antigens, which can activate cross‐reactive lymphocytes that attack ...
Bandar A Suliman
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Molecular mimicry and cancer vaccine development [PDF]
Molecular Cancer, 2023 Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte +6 more
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Visiting Molecular Mimicry Once More: Pathogenicity, Virulence, and Autoimmunity [PDF]
Microorganisms, 2023 The concept of molecular mimicry describes situations in which antigen sharing between parasites and hosts could benefit pathogen evasion from host immune responses.
Yuri Chaves Martins +2 more
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Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins
Viruses, 2022 Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic
Janelle Nunez-Castilla +10 more
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The interplay between viral molecular mimicry and host chromatin dynamics [PDF]
Nucleus, 2023 Molecular mimicry is a commonly used mechanism by viruses to manipulate host cellular machinery and coordinate their life cycles. While histone mimicry is well studied, viruses also employ other mimicry strategies to affect chromatin dynamics.
Shumin Xiao +3 more
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Molecular mimicry between SARS‐CoV‐2 and the female reproductive system [PDF]
American Journal of Reproductive Immunology, 2021 Oogenesis, the process of egg production by the ovary, involves a complex differentiation program leading to the production of functional oocytes. This process comprises a sequential pathway of steps that are finely regulated.
Arad Dotan +4 more
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Identification of potential molecular mimicry in pathogen-host interactions [PDF]
PeerJ, 2023 Pathogens have evolved sophisticated strategies to manipulate host signaling pathways, including the phenomenon of molecular mimicry, where pathogen-derived biomolecules imitate host biomolecules.
Kaylee D. Rich +3 more
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Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis. [PDF]
Dig Dis Sci, 2023 Molecular mimicry between foreign and self-antigens has been implicated as a cause of autoimmune hepatitis in experimental models and cross-reacting antibodies in patients.
Czaja AJ.
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Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases [PDF]
Journal of Translational AutoimmunityAutoimmune rheumatic diseases (ARDs) are a heterogeneous group of conditions characterized by excessive and misdirected immune responses against the body's own musculoskeletal tissues.
Michaela Fehringer, Thomas Vogl
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