Results 111 to 120 of about 3,774,726 (329)

Molecular Mimicry and Autoimmunity

, 2015
The term Molecular mimicry describes the sequence similarity between foreign (microorganism's peptides) and self peptides (the host's antigen). This phenomenon has been recently discovered as a one of the major mechanism in which there is a break-down of self-tolerance of the immune system following autoimmunity.
Maoz-Segal, Ramit, Andrade, Paulo
openaire   +1 more source

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

Scientific Reports, 2016
Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise.
Marine C. C. Raman, P. Rizkallah, Ruth Simmons, Zoe Donnellan, J. Dukes, G. Bossi, Gabrielle S Le Provost, P. Todorov, Emma Baston, E. Hickman, T. Mahon, N. Hassan, A. Vuidepot, Malkit Sami, D. Cole, B. Jakobsen   +15 more
semanticscholar   +1 more source

Elucidating and Biomimicking the Coloration Mechanisms Responsible for the Vibrant Blue Hues of the Common Kingfisher

Advanced Optical Materials, EarlyView.
This study reveals why the back feathers of a common kingfisher show various non‐iridescent blueish structural colors by analyzing the internal structures of the feathers. It demonstrates how structural differences lead to the different optical interactions, thereby producing different colors.
Jihun Kang, Seunghwan Moon, Deok‐Jin Jeon, Seungmuk Ji, Eunok Lee, Jong‐Souk Yeo   +5 more
wiley   +1 more source

Neural measures of the causal role of observers' facial mimicry on visual working memory for facial expressions [PDF]

arXiv, 2018
Simulation models of facial expressions propose that sensorimotor regions may increase the clarity of facial expressions representations in extrastriate areas. We monitored the event-related potential marker of visual working memory (VWM) representations, namely the sustained posterior contralateral negativity (SPCN), also termed contralateral delay ...
arxiv  

Molecular mimicry in multiple sclerosis

Autoimmunity, 2006
Two main etiological components are considered important in human autoimmune diseases including multiple sclerosis (MS), first the immunogenetic background and second environmental factors. Among the latter, infectious organisms are probably the most relevant, and epidemiological studies in MS firmly support that viral infections often precede disease ...
Roland Martin, Mireia Sospedra
openaire   +3 more sources

Chemical AI in the Limelight: The Contribution of Photochromic Materials and Oscillatory Chemical Reactions

Advanced Optical Materials, EarlyView.
Photochromic compounds are versatile ingredients for the development of Chemical AI. When they are embedded in a tight microenvironment, they become Markov blankets. They are also valuable for processing Boolean and Fuzzy logic. They contribute to neuromorphic engineering in wetware based on opto‐chemical signals exchanged with oscillatory chemical ...
Pier Luigi Gentili
wiley   +1 more source

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms

Viruses, 2019
For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal ...
Maria K. Smatti, Farhan S. Cyprian, Gheyath K. Nasrallah, Asmaa A. Al Thani, Ruba O. Almishal, Hadi M. Yassine   +5 more
doaj   +1 more source

Bacterial molecular mimicry in autoimmune diseases

Current Bioscience, 2021
Bacterial molecular mimicry in autoimmune diseases is one of the leading mechanisms by which microorganisms may induce autoimmunity and survive in the host. The main purpose of the current study was to determine the main microbes that elicit autoimmune reactions through molecular mimicry and identify the most relevant approaches to investigate this ...
openaire   +4 more sources

Genome-wide analysis of genetic risk factors for rheumatic heart disease in Aboriginal Australians provides support for pathogenic molecular mimicry

bioRxiv, 2017
Background Rheumatic heart disease (RHD) following Group A Streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers pro-inflammatory cardiac valve-reactive T-cells ...
Lesley-Ann Gray, H. D’Antoine, S. Y. Tong, Melita McKinnon, D. Bessarab, Ngiare J Brown, B. Reményi, A. Steer, Genevieve Syn, J. Blackwell, M. Inouye, J. Carapetis   +11 more
semanticscholar   +1 more source