Results 111 to 120 of about 4,511,721 (218)
PLoS Neglected Tropical Diseases, 2017 Background Chikungunya virus (CHIKV), a reemerging pathogen causes a self limited illness characterized by fever, headache, myalgia and arthralgia. However, 10–20% affected individuals develop persistent arthralgia which contributes to considerable ...
Vijayalakshmi Reddy +3 more
semanticscholar +1 more source
Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
Viruses, 2019 For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal ...
Maria K. Smatti +5 more
doaj +1 more source
Molecular mimicry in autoimmune disease [PDF]
Archives of Disease in Childhood, 1998 The origins of autoimmune disease are multifactorial. Environmental factors and a genetic predisposition result in tissue injury caused by autoreactive T cells or antibodies. Usually a single organ or individual cell type is affected in the absence of gross abnormalities of the immune system.
openaire +2 more sources
Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]
, 2009 The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs +2 more
core
Molecular Mimicry in Multiple Sclerosis
, 2007 One of the most common demyelinating central nervous system (CNS) diseases in humans is multiple sclerosis (MS). The disease can be very debilitating with vision loss, motor and sensory disturbances, and cognitive impairment. The clinical course may present as a relapsing-remitting disease course, a progressive disease course, or a combination thereof.
Libbey, Jane E. +2 more
openaire +2 more sources
Trends in immunology, 2017 Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system (CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote MS remains unclear.
J. Geginat +6 more
semanticscholar +1 more source
Cell, 1995 Structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell response. Based on the structural requirements for both MHC class 11 binding and TCR recognition of an immunodominant myelin ...
K. Wucherpfennig, J. Strominger
semanticscholar +1 more source
Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion. [PDF]
, 2019 Group A Streptococcus (GAS) is a human-specific pathogen that evades the host immune response through the elaboration of multiple virulence factors. Although many of these factors have been studied, numerous proteins encoded by the GAS genome are of ...
Campeau, Anaamika +14 more
core
Making Distinct Dynamical Systems Appear Spectrally Identical
, 2017 We show that a laser pulse can always be found that induces a desired optical response from an arbitrary dynamical system. As illustrations, driving fields are computed to induce the same optical response from a variety of distinct systems (open and ...
Bondar, Denys I. +3 more
core +1 more source
An evolutionary approach to Function
, 2013 Background: Understanding the distinction between function and role is vexing and difficult. While it appears to be useful, in practice this distinction is hard to apply, particularly within biology.
Lord, Phillip
core +1 more source