Results 21 to 30 of about 3,780,564 (348)

Molecular Mimicry Mapping in Streptococcus pneumoniae: Cues for Autoimmune Disorders and Implications for Immune Defense Activation [PDF]

Pathogens, 2023
Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon of molecular mimicry, which, in turn, may contribute to the ...
Mutaib M. Mashraqi, Ahmad Alzamami, Norah A. Alturki, Saleh Alshamrani, Mousa M. Alshahrani, Hassan H. Almasoudi, Zarrin Basharat   +6 more
doaj   +2 more sources

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach [PDF]

Microorganisms, 2023
Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble host antigens, has been proposed as a potential trigger for autoimmune responses.
Saleh Alshamrani, Mutaib M. Mashraqi, Ahmad Alzamami, Norah A. Alturki, Hassan H. Almasoudi, Mohammed Abdulrahman Alshahrani, Zarrin Basharat   +6 more
doaj   +2 more sources

T Cell Allorecognition via Molecular Mimicry [PDF]

Immunity, 2009
T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the LC13 T cell receptor (TCR), selected for recognition on self-HLA-B( *)0801 bound to a viral peptide, alloreacts with B44 allotypes (HLA-B( *)4402 and HLA-B( *)4405) bound to two different allopeptides.
W.A. Macdonald, Zhenjun Chen, Stéphanie Gras, Julia K. Archbold, F.E. Tynan, Craig S. Clements, Mandvi Bharadwaj, Lars Kjer‐Nielsen, Philippa M. Saunders, Matthew C. J. Wilce, F. T. Crawford, B. Stadinsky, David C. Jackson, Andrëw G. Brööks, Anthony W. Purcell, John W. Kappler, Scott R. Burrows, Jamie Rossjohn, James McCluskey   +18 more
openalex   +6 more sources

Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity

Frontiers in Microbiology, 2017
Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes.
Susanta Pahari, Susanta Pahari, Deepyan Chatterjee, Shikha Negi, Jagdeep Kaur, Balvinder Singh, Javed N. Agrewala   +6 more
doaj   +2 more sources

Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico.

PLoS ONE, 2022
Microbial mimicry of the host proteins/peptides can elicit host auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved in several host cell signaling and PPI networks, molecular
Anjali Garg, Govinda Rao Dabburu, Neelja Singhal, Manish Kumar   +3 more
doaj   +2 more sources

Phylogenetic Codivergence Supports Coevolution of Mimetic Heliconius Butterflies [PDF]

, 2012
The unpalatable and warning-patterned butterflies _Heliconius erato_ and _Heliconius melpomene_ provide the best studied example of mutualistic Müllerian mimicry, thought – but rarely demonstrated – to promote coevolution.
AJ Drummond, AJ Eckert, AVZ Brower, AVZ Brower, B Charlesworth, BA Counterman, C Conow, C Zhang, CEG Pinheiro, CF Arias, Corrie S. Moreau, D Posada, DD Kapan, DH Janzen, DJ Futuyma, DJ Futyma, DL Swofford, EB Wilson, F Müller, FS Ceccarelli, G Jobb, G Lamas, GA Watterson, H Akaike, H Eltringham, H Engler, H Shimodaira, HM Hines, HW Bates, J Heled, J Hey, J Mallet, J Mallet, J Wakely, JE McCormack, Jennifer Hoyal Cuthill, JKS Brown, JN Thompson, JN Thompson, JRG Turner, KS Brown, LE Gilbert, LE Gilbert, M Beltrán, M Beltrán, M Heikkilä, M Joron, MA Charleston, MA Charleston, Michael Charleston, MR Kronforst, MR Kronforst, NA Rosenberg, NS Flanagan, P Chai, Page, PM Sheppard, R Frankham, RC Edgar, RD Reed, S Gandon, S Knapp, S Wright, S-P Quek, SW Baxter, TJ Simonsen, WP Maddison, WP Maddison, WP Maddison, WW Benson, Z Yang   +70 more
core   +19 more sources

Molecular (epitopic) mimicry phenomenon in Lime arthritis

Научно-практическая ревматология, 2004
Л П Ананьева
openalex   +3 more sources

Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?

Pathophysiology, 2022
Molecular mimicry between human and microbial/viral/parasite peptides is common and has long been associated with the etiology of autoimmune disorders provoked by exogenous pathogens.
L. Churilov, M. G. Normatov, V. Utekhin
semanticscholar   +1 more source

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Science, 2022
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and future zoonotic sarbecoviruses.
Young-Jun Park, A. De Marco, Tyler N. Starr, Zhuoming Liu, D. Pinto, A. Walls, F. Zatta, Samantha K. Zepeda, John E. Bowen, Kaitlin R. Sprouse, Anshu Joshi, M. Giurdanella, B. Guarino, Julia Noack, R. Abdelnabi, S. Foo, Laura E. Rosen, Florian A. Lempp, F. Benigni, G. Snell, J. Neyts, S. Whelan, H. Virgin, J. Bloom, D. Corti, M. Pizzuto, D. Veesler   +26 more
semanticscholar   +1 more source

A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

bioRxiv, 2022
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is development of autoantibodies and T-cells directed at an epitope in the B-chain of insulin (insB:9-23 ...
K. Girdhar, Qian Huang, I-Ting Chow, T. Vatanen, C. Brady, Amol Raisingani, P. Autissier, M. Atkinson, W. Kwok, C. Kahn, E. Altindis   +10 more
semanticscholar   +1 more source