Results 21 to 30 of about 3,774,726 (329)

miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry

Frontiers in Microbiology, 2017
Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e., similarity between the host's and pathogen's interacting peptides is an important reason. In the present study we have reported a database of only experimentally verified
Anjali Garg, Bandana Kumari, Ravindra Kumar, Manish Kumar   +3 more
doaj   +2 more sources

Molecular Mimicry in Multiple Sclerosis

, 2007
One of the most common demyelinating central nervous system (CNS) diseases in humans is multiple sclerosis (MS). The disease can be very debilitating with vision loss, motor and sensory disturbances, and cognitive impairment. The clinical course may present as a relapsing-remitting disease course, a progressive disease course, or a combination thereof.
Jane E. Libbey, Lori McCoy, Robert S. Fujinami   +2 more
openalex   +4 more sources

Guillain-Barré syndrome: expanding the concept of molecular mimicry. [PDF]

Trends Immunol, 2022
Laman JD, Huizinga R, Boons GJ, Jacobs BC.   +3 more
europepmc   +2 more sources

Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity

Frontiers in Microbiology, 2017
Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes.
Susanta Pahari, Susanta Pahari, Deepyan Chatterjee, Shikha Negi, Jagdeep Kaur, Balvinder Singh, Javed N. Agrewala   +6 more
doaj   +2 more sources

T Cell Allorecognition via Molecular Mimicry [PDF]

Immunity, 2009
T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the LC13 T cell receptor (TCR), selected for recognition on self-HLA-B( *)0801 bound to a viral peptide, alloreacts with B44 allotypes (HLA-B( *)4402 and HLA-B( *)4405) bound to two different allopeptides.
W.A. Macdonald, Zhenjun Chen, Stéphanie Gras, Julia K. Archbold, F.E. Tynan, Craig S. Clements, Mandvi Bharadwaj, Lars Kjer‐Nielsen, Philippa M. Saunders, Matthew C. J. Wilce, F. T. Crawford, B. Stadinsky, David C. Jackson, Andrëw G. Brööks, Anthony W. Purcell, John W. Kappler, Scott R. Burrows, Jamie Rossjohn, James McCluskey   +18 more
openalex   +6 more sources

Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico.

PLoS ONE, 2022
Microbial mimicry of the host proteins/peptides can elicit host auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved in several host cell signaling and PPI networks, molecular
Anjali Garg, Govinda Rao Dabburu, Neelja Singhal, Manish Kumar   +3 more
doaj   +2 more sources

Molecular (epitopic) mimicry phenomenon in Lime arthritis

Научно-практическая ревматология, 2004
Л П Ананьева
doaj   +2 more sources

Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?

Pathophysiology, 2022
Molecular mimicry between human and microbial/viral/parasite peptides is common and has long been associated with the etiology of autoimmune disorders provoked by exogenous pathogens.
L. Churilov, M. G. Normatov, V. Utekhin
semanticscholar   +1 more source

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Science, 2022
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and future zoonotic sarbecoviruses.
Young-Jun Park, A. De Marco, Tyler N. Starr, Zhuoming Liu, D. Pinto, A. Walls, F. Zatta, Samantha K. Zepeda, John E. Bowen, Kaitlin R. Sprouse, Anshu Joshi, M. Giurdanella, B. Guarino, Julia Noack, R. Abdelnabi, S. Foo, Laura E. Rosen, Florian A. Lempp, F. Benigni, G. Snell, J. Neyts, S. Whelan, H. Virgin, J. Bloom, D. Corti, M. Pizzuto, D. Veesler   +26 more
semanticscholar   +1 more source

A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

bioRxiv, 2022
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is development of autoantibodies and T-cells directed at an epitope in the B-chain of insulin (insB:9-23 ...
K. Girdhar, Qian Huang, I-Ting Chow, T. Vatanen, C. Brady, Amol Raisingani, P. Autissier, M. Atkinson, W. Kwok, C. Kahn, E. Altindis   +10 more
semanticscholar   +1 more source