Results 21 to 30 of about 2,281 (156)

miPepBase: A Database of Experimentally Verified Peptides Involved in Molecular Mimicry

Frontiers in Microbiology, 2017
Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e., similarity between the host's and pathogen's interacting peptides is an important reason. In the present study we have reported a database of only experimentally verified
Anjali Garg, Bandana Kumari, Ravindra Kumar, Manish Kumar   +3 more
doaj   +1 more source

Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins

Global Medical Genetics, 2023
This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen.
Darja Kanduc
doaj   +1 more source

Decoding the relationship between cow’s milk proteins and development of type 1 diabetes mellitus [PDF]

Archives of Endocrinology and Metabolism
Objective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger.
Luís Jesuino de Oliveira Andrade, Gabriela Correia Matos de Oliveira, Luísa Correia Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Yvana Baumgarth, Luís Matos de Oliveira   +5 more
doaj   +1 more source

The impact of antigenic molecular mimicry on anti-cancer T-cell immune response

Frontiers in Oncology, 2022
Individuals are exposed to intracellular pathogens (i.e. viruses and intracellular bacteria) and intestinal microbiota, collectively microorganisms (MOs), which enter the body during the host’s lifetime.
Maria Tagliamonte, Luigi Buonaguro
doaj   +1 more source

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects. [PDF]

PLoS ONE, 2015
Previous studies in HIV patients have reported autoantibodies to several human proteins, including erythropoietin (EPO), interferon-α (IFN-α), interleukin-2 (IL-2), and HLA-DR, as potential mediators of anemia or immunosuppression.
Peter D Burbelo, James S Klimavicz, Steve G Deeks, Joseph A Kovacs, Jack A Ragheb   +4 more
doaj   +1 more source

Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity

Pathogens, 2022
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate.
Sara Begum, Sara Aiman, Shujaat Ahmad, Abdus Samad, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Sahib Gul Afridi, Asifullah Khan   +8 more
doaj   +1 more source

EMoMiS: A pipeline for epitope-based molecular mimicry search in protein structures with potential applications to SARS-CoV-2

Computational and Structural Biotechnology Journal
The Epitope-based Molecular Mimicry Search (EMoMiS) pipeline developed in this study provides a valuable computational tool for predicting molecular mimicry between antigens.
Vitalii Stebliankin, Rajeshwari Chellappan, Prabin Baral, Christian Balbin, Janelle Nunez-Castilla, Masrur Sobhan, Trevor Cickovski, Ashleigh N. Riegler, Ananda Mohan Mondal, Jessica Siltberg-Liberles, Prem Chapagain, Sathibalan Ponniah, Sixto M. Leal, Jr, Kalai Mathee, Giri Narasimhan   +14 more
doaj   +1 more source

Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy

Brazilian Journal of Medical and Biological Research, 2005
Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry.
F. García-Vallejo, M.C. Domínguez, O. Tamayo   +2 more
doaj   +1 more source

Potential clinical implications of molecular mimicry‐induced autoimmunity

Immunity, Inflammation and Disease
Background Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self‐antigens, which can activate cross‐reactive lymphocytes that attack ...
Bandar A Suliman
doaj   +1 more source

Molecular mimicry and autoimmunity

Journal of Autoimmunity, 2018
Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual.
Rojas Quintana, Manuel Eduardo, Restrepo-Jiménez, Paula, Monsalve Carmona, Diana Marcela, Acosta Ampudia, Yeny Yasbleidy, Ramírez Santana, Heily Carolina, Leung, Patrick S.C., Ansari, Aftab A., Gershwin, M. Eric, Anaya, Juan-Manuel, Pacheco Nieva, Yovana   +9 more
openaire   +3 more sources