Results 21 to 30 of about 4,511,721 (218)

Microbiome, Parkinson’s Disease and Molecular Mimicry

Cells, 2019
Parkinson’s Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external ...
Fabiana Miraglia, Emanuela Colla
doaj   +2 more sources

Molecular mimicry between parasites and cancer: a novel approach for developing cancer vaccines and therapeutic antibodies [PDF]

Cancer Immunology, Immunotherapy
Cancer is one of the most dreaded diseases worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and adverse effects. Cancer immunotherapy and targeted therapies offer new treatment options.
Maha Mohamed Eissa, Sonia Rifaat Ahmed Allam, Cherine Adel Ismail, Rasha Abdelmawla Ghazala, Nahla El Skhawy, Eman Ibrahim El-said Ibrahim   +5 more
doaj   +2 more sources

Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity

Frontiers in Microbiology, 2017
Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes.
Susanta Pahari, Susanta Pahari, Deepyan Chatterjee, Shikha Negi, Jagdeep Kaur, Balvinder Singh, Javed N. Agrewala   +6 more
doaj   +2 more sources

Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico.

PLoS ONE, 2022
Microbial mimicry of the host proteins/peptides can elicit host auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved in several host cell signaling and PPI networks, molecular
Anjali Garg, Govinda Rao Dabburu, Neelja Singhal, Manish Kumar   +3 more
doaj   +2 more sources

Genes Suggest Ancestral Colour Polymorphisms Are Shared across Morphologically Cryptic Species in Arctic Bumblebees [PDF]

, 2015
email Suzanne orcd idCopyright: © 2015 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
A Bertsch, A Bertsch, A Cardoso, A Estoup, A Løken, A Papadopoulou, A Pekkarinen, AJ Drummond, Alexandr M. Byvaltsev, AS Skorikov, AS Skorikov, B Pittioni, B Tkalcu, B Tkalcu, BC Schlick-Steiner, BG Svensson, BG Svensson, Björn Cederberg, CD Michener, Claus Rasmussen, Cory S. Sheffield, D Baum, DR Maddison, DV Panfilov, E Krüger, EO Wilson, F Leliaert, Frode Ødegaard, G Talavera, GF Barrowclough, H Friese, H Pringle, H Song, HE Milliron, HM Hines, HM Hines, IC Barro, J Brigham-Grette, J Mallet, J Pons, J-J Zhang, J-X Huang, JC Carolan, Jiaxing Huang, JO Gjershaug, JP Huelsenbeck, JP Strange, K de Queiroz, K Tamura, KJ Gaston, KN Magnacca, KW Richards, KW von Dalla Torre, Leif L. Richardson, M Terzo, MA Duennes, Mikhail V. Berezin, MK Fujita, MP Cristiano, MR Kronforst, MT Monaghan, MT Monaghan, NM Reid, O Radoszkowski, O Vogt, O Vogt, OW Richards, OW Richards, P Pamilo, P Rasmont, P Rasmont, P Rasmont, Paul H. Williams, PDN Hebert, PDN Hebert, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, PH Williams, R Neumeyer, R Rougerie, RC Plowright, RM Zink, RM Zink, S Ratnasingham, SA Cameron, SA Elias, ST Williams, Suzanne T. Williams, SV Edwards, T De Meulemeester, T Fujisawa, T Lecocq, T Lecocq, T Lecocq, T Lecocq, WF Reinig, WF Reinig, WF Reinig, WP Maddison, Z Rapti, Zuogang Peng   +107 more
core   +23 more sources

Guillain-Barré syndrome: expanding the concept of molecular mimicry.

Trends in immunology, 2022
Guillain-Barré syndrome (GBS) is a rapidly progressive, monophasic, and potentially devastating immune-mediated neuropathy in humans. Preceding infections trigger the production of cross-reactive antibodies against gangliosides concentrated in human ...
J. Laman, R. Huizinga, G. Boons, B. Jacobs   +3 more
semanticscholar   +1 more source

Molecular Mimicry between SARS-CoV-2 and Human Endocrinocytes: A Prerequisite of Post-COVID-19 Endocrine Autoimmunity?

Pathophysiology, 2022
Molecular mimicry between human and microbial/viral/parasite peptides is common and has long been associated with the etiology of autoimmune disorders provoked by exogenous pathogens.
L. Churilov, M. G. Normatov, V. Utekhin
semanticscholar   +1 more source

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

Science, 2022
Understanding broadly neutralizing sarbecovirus antibody responses is key to developing countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and future zoonotic sarbecoviruses.
Young-Jun Park, A. De Marco, Tyler N. Starr, Zhuoming Liu, D. Pinto, A. Walls, F. Zatta, Samantha K. Zepeda, John E. Bowen, Kaitlin R. Sprouse, Anshu Joshi, M. Giurdanella, B. Guarino, Julia Noack, R. Abdelnabi, S. Foo, Laura E. Rosen, Florian A. Lempp, F. Benigni, G. Snell, J. Neyts, S. Whelan, H. Virgin, J. Bloom, D. Corti, M. Pizzuto, D. Veesler   +26 more
semanticscholar   +1 more source

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +1 more source

A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes

bioRxiv, 2022
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is development of autoantibodies and T-cells directed at an epitope in the B-chain of insulin (insB:9-23 ...
K. Girdhar, Qian Huang, I-Ting Chow, T. Vatanen, C. Brady, Amol Raisingani, P. Autissier, M. Atkinson, W. Kwok, C. Kahn, E. Altindis   +10 more
semanticscholar   +1 more source