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Parasitology Today, 1987
The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
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The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
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2007
Molecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross-reactivity. Molecular mimicry has been demonstrated to occur in several different forms including complete identity at the protein level, homology at the protein level ...
Robert S. Fujinami, Lisa K. Peterson
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Molecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross-reactivity. Molecular mimicry has been demonstrated to occur in several different forms including complete identity at the protein level, homology at the protein level ...
Robert S. Fujinami, Lisa K. Peterson
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Molecular Mimicry in Multiple Sclerosis
New England Journal of Medicine, 2003Molecular mimicry is a model in which foreign antigens are sufficiently similar to native antigens to trigger an autoimmune response. A study involving the specificity of a T-cell receptor derived from a patient with multiple sclerosis indicates that molecular mimicry extends to complexes of proteins — a finding with implications for therapy.
Hartmut Wekerle, Reinhard Hohlfeld
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Tropomyosin and molecular mimicry
Parasitology Today, 1991cyst investiture in nonmuscle tropo- myosin may play a role in immune evasion in the snail host by protecting the sporocyst from amoebocyte attack. If true, this would be a prime example of molecular mimicry in its full and original sense s , which links common structures to the host-parasite relationship.
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Molecular Mimicry in Mercury Toxicology
Chemical Research in Toxicology, 2006Molecular mimicry occurs when one molecular entity is "mistaken" for another by cellular or other biological processes, and is thought to arise from structural similarities between the two molecules in question. It has been postulated by others to be important in the mechanism of uptake of toxic metal species into living tissues.
Hoffmeyer, R. +6 more
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Malaria and ovalocytosis — molecular mimicry?
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1991Two recently published reports have described findings which will have a profound impact on the understanding of molecular mechanisms of human resistance to malaria infection. In Melanesian ovalocytosis, a genetic polymorphism found in Papua New Guinea and parts of South East Asia, the red cells are highly resistant to invasion by various species of ...
Paul Ruff, A. Husain-Chishti
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Molecular Mimicry and Diabetes
1989Insulin-dependent diabetes (IDDM) often develops early in life and is associated with lifelong insulin treatment, a reduced life span, and serious long-term complications (Borch-Johnsen et al. 1986). Other forms of diabetes exist (National Diabetes Data Group 1979), e.g., noninsulin-dependent diabetes, maturity onset diabetes in the young (MODY), and ...
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Molecular Mimicry of Carbohydrates by Peptides
Australian Journal of Chemistry, 2002The use of carbohydrates as drugs and vaccines has several limitations. Molecular mimics of carbohydrates provide an alternative source of compounds to target pathways involving protein-carbohydrate interactions. In recent years, immunological studies have demonstrated the ability of certain peptides to act as molecular mimics of carbohydrates, in that
Margaret A. Johnson, B.M. Pinto
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Structural Basis of Molecular Mimicry
Journal of Autoimmunity, 2001Infectious agents are thought to play an important role in the development of autoimmune diseases. Sequence similarity between infectious agents and self-proteins (molecular mimicry) has been proposed as a mechanism for the induction of autoimmunity [1].
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2014
The term molecular mimicry was originally used by Raymon T. Damian to describe the sharing of antigenic structures, such as proteins, lipids, or carbohydrates, by parasite and host. In terms of autoimmune-like reactions, Damian referred to a work by Rowley and Jenkin published in 1962.
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The term molecular mimicry was originally used by Raymon T. Damian to describe the sharing of antigenic structures, such as proteins, lipids, or carbohydrates, by parasite and host. In terms of autoimmune-like reactions, Damian referred to a work by Rowley and Jenkin published in 1962.
openaire +2 more sources