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Arthritis &Rheumatology, EarlyView.Objective Endogenous retroelements (EREs) stimulate type 1 interferon (IFN‐I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN‐I levels are increased.
Faye A. H. Cooles +12 more
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Chemistry – An Asian Journal, EarlyView.The preparation and characterization of the first helical pyrazino‐phenanthroline ligand, namely [4]helicene‐pyrazino[2,3‐f][1,10]phenanthroline (H4PP) and its corresponding Re(CO)3Cl complex (Re‐H4PP) are described. The photophysics and chiroptics (circular dichroism and circularly polarized luminescence) of these new chiral systems are thoroughly ...
Debsouri Kundu +5 more
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Biotechnology and Bioengineering, EarlyView.Dash and coworkers have fabricated a small intestine on a chip, which encapsulates the physiology and biofilm of the small intestinal epithelium. The dynamic system showed villus differentiation within 5 days of flow, and the mucus layer and biofilm showed small intestinal characteristics.
Sanat Kumar Dash +2 more
wiley +1 more source
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Molecular mimicry or structural mimicry?
Molecular Immunology, 2006"Molecular mimicry" should be changed to "structural mimicry". The immune system recognizes shapes--three-dimensional shapes--not sequences. For two sequences to act biologically similar they must possess similar three-dimensional structures.
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Molecular mimicry and auto-immunity
Clinical Reviews in Allergy & Immunology, 2007The term "molecular mimicry" was coined by R. Damian in 1964, who was first to suggest that antigenic determinants of micro-organisms may resemble antigenic determinants of their host. Damian suggested that this similarity served as a defense mechanism of a microorganism from the host's immune system and prevented the development of immune response to ...
Ori Barzilai +2 more
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Chemokine receptors and molecular mimicry
Immunology Today, 1994Chemokines are small pro-inflammatory peptides that are best known for their leukocyte-chemoattractant activity. The cloned leukocyte chemokine receptors, interleukin 8 receptor (IL-8R) types A and B and the macrophage inflammatory protein 1 alpha (MIP-1 alpha)/RANTES receptor, are related by sequence and chemokine binding to two herpesvirus products ...
Ji Liang Gao +2 more
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Parasitology Today, 1987
The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
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The host immune response is an important line of defence against parasites. Tactics to evade this response are therefore expected in host-parasite relationships, and the clearest example is the antigenic variation displayed by African trypanosomes. But while few other parasites seem to have quite this ability, many seem to display a form of antigenic ...
openaire +3 more sources
Molecular Mimicry in Multiple Sclerosis
New England Journal of Medicine, 2003Molecular mimicry is a model in which foreign antigens are sufficiently similar to native antigens to trigger an autoimmune response. A study involving the specificity of a T-cell receptor derived from a patient with multiple sclerosis indicates that molecular mimicry extends to complexes of proteins — a finding with implications for therapy.
Hartmut Wekerle, Reinhard Hohlfeld
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2007
Molecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross-reactivity. Molecular mimicry has been demonstrated to occur in several different forms including complete identity at the protein level, homology at the protein level ...
Robert S. Fujinami, Lisa K. Peterson
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Molecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross-reactivity. Molecular mimicry has been demonstrated to occur in several different forms including complete identity at the protein level, homology at the protein level ...
Robert S. Fujinami, Lisa K. Peterson
openaire +2 more sources