Results 241 to 250 of about 2,063,348 (292)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Identification of a molecular network regulated by multiple ASD high risk genes. [PDF]

Hum Mol Genet
Wan L, Yang G, Yan Z.
europepmc   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Rare and common variants associated with alcohol consumption identify a conserved molecular network. [PDF]

Alcohol Clin Exp Res (Hoboken)
Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S, Palmer AA.   +4 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A multi-source molecular network representation model for protein-protein interactions prediction. [PDF]

Sci Rep
Zou HT, Ji BY, Xie XL.
europepmc   +1 more source

Molecular network analysis of CPEB4 translational control and targeting CPEB4/β-catenin to modulate invasion and migration of nasopharyngeal carcinoma cells. [PDF]

Int J Med Sci
Fen L, Yuanyuan W, Tian C, Yingying W, Yongping W, Mingwan Z, Fuhai C, Manli Z, Zezhang T.   +8 more
europepmc   +1 more source

Molecular-Network Transformations in Tetra-Arsenic Triselenide Glassy Alloys Tuned within Nanomilling Platform. [PDF]

Molecules
Shpotyuk O, Hyla M, Shpotyuk Y, Lukáčová Bujňáková Z, Baláž P, Demchenko P, Kozdraś A, Boyko V, Kovalskiy A.   +8 more
europepmc   +1 more source

Nanostructured Molecular-Network Arsenoselenides from the Border of a Glass-Forming Region: A Disproportionality Analysis Using Complementary Characterization Probes. [PDF]

Molecules
Shpotyuk O, Hyla M, Ingram A, Shpotyuk Y, Boyko V, Demchenko P, Wojnarowska-Nowak R, Lukáčová Bujňáková Z, Baláž P.   +8 more
europepmc   +1 more source

Bioactive Metabolites from the Dusty Seeds of <i>Gastrodia elata</i> Bl., Based on Metabolomics and UPLC-Q-TOF-MS Combined with Molecular Network Strategy. [PDF]

Plants (Basel)
Wang Y, Zhong L, Fang H, Liu Z, Wang P, Li L, Chen L, Ding G.   +7 more
europepmc   +1 more source