Results 241 to 250 of about 1,062,909 (310)

Molecular Network Analysis of Circulating microRNAs Highlights miR-17-5p and miR-29a-3p as Potential Biomarkers of Aortic Valve Calcification. [PDF]

Int J Mol Sci
Galeone A, Minoia A, Braggio M, Cominacini M, Romanelli MG, Dalle Carbonare L, Faggian G, Luciani GB, Valenti MT.   +8 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Letter to the editor: a commentary on "Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin b1-induced hepatocellular carcinoma". [PDF]

Int J Surg
Wang T, Hu H, Qin C, Luo H, Wang J.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

HIV molecular network in Mexico City (2021-2022): Understanding transmission dynamics through the role of newly diagnosed cases. [PDF]

HIV Med
Schulz-Medina SE, Tapia-Trejo D, Matías-Florentino M, López-Sánchez DM, García-Morales C, Monreal-Flores J, Beristain-Barreda Á, Cárdenas-Sandoval M, Becerril-Rodríguez M, Del Arenal-Sánchez S, Quiroz-Morales V, Weaver S, Wertheim JO, Cruz-Flores RA, Reyes-Terán G, González-Rodríguez A, Ávila-Ríos S, Dávila-Conn V.   +17 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis. [PDF]

J Transl Med
Jiang P, Zhao Y, Jia Y, Ma H, Guo Y, Yan W, Xi X.   +6 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Understanding the Paradigm of Molecular-Network Conformations in Nanostructured Se-Rich Arsenoselenides As_xSe_100-x (x < 10). [PDF]

Molecules
Shpotyuk O, Lukáčová Bujňáková Z, Shpotyuk Y, Kovalskiy A.   +3 more
europepmc   +1 more source