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Molecular networks in Network Medicine: Development and applications [PDF]
AbstractNetwork Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including proteināprotein interaction networks, correlationābased networks, gene regulatory networks, and Bayesian networks.
Edwin K Silverman +2 more
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Nature Biotechnology, 2015
Network biology is beginning to tackle the complexities of multicellular systems and disease associations.
Andrew M, Gross, Trey, Ideker
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Network biology is beginning to tackle the complexities of multicellular systems and disease associations.
Andrew M, Gross, Trey, Ideker
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MOLECULAR NETWORKS IN MICROARRAY ANALYSIS
Journal of Bioinformatics and Computational Biology, 2007Microarray-based characterization of tissues, cellular and disease states, and environmental condition and treatment responses provides genome-wide snapshots containing large amounts of invaluable information. However, the lack of inherent structure within the data and strong noise make extracting and interpreting this information and formulating and ...
Andrey Y. Sivachenko +3 more
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Molecular Characterization of Polymer Networks
Chemical Reviews, 2021Polymer networks are complex systems consisting of molecular components. Whereas the properties of the individual components are typically well understood by most chemists, translating that chemical insight into polymer networks themselves is limited by the statistical and poorly defined nature of network structures.
Scott P. O. Danielsen +16 more
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The Human Molecular Genetics Network
New England Journal of Medicine, 1995To the Editor: With regard to your editorial on the Internet and the Journal (June 22 issue),1 the availability of biomedical services on the Internet promises to change many aspects of contemporar...
Gambacorti-Passerini, Carlo +2 more
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Molecular networks of brain and immunity
Brain Research Reviews, 2007Exciting complexity of natural phenomena can be based on rather simple biophysical principles. For example, the genetic code is based on a double-helix of DNA formed by planar geometry of weak hydrogen bounds. On the examples of cytokine networks, immune synapse, psychoneuroimmunology and systems biology, this review paper attempts to show how ...
Larisa B, Goncharova +1 more
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SELFORGANIZATION IN MOLECULAR AND CELLULAR NETWORKS
Neurochemistry International, 1980Biological organisation rests on forces among material constituents which manifest themselves in two principal forms, namely as static-conservative and as dynamic-dissipative, the latter being responsible for selforganisational and regulatory behaviour.
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Self-organizing molecular networks
Biophysical Chemistry, 1998Strong diffusional mixing and short delivery times typical for micrometer and sub-micrometer reaction volumes lead to a special situation where the turnover times of individual enzyme molecules become the largest characteristic time scale of the chemical kinetics. Under these conditions, populations of cross-regulating allosteric enzymes form molecular
Stange, P. +3 more
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