Results 51 to 60 of about 4,381,034 (355)

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source

ER stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling

iScience
Summary: Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking.
Lluis Miquel-Rio, Unai Sarriés-Serrano, María Sancho-Alonso, Eva Florensa-Zanuy, Verónica Paz, Esther Ruiz-Bronchal, Sharon Manashirov, Leticia Campa, Fuencisla Pilar-Cuéllar, Analia Bortolozzi   +9 more
doaj   +1 more source

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System

iScience, 2020
Summary: Extracellular vesicles (EVs) are important mediators of intercellular communication. Interest in the role of central nervous system (CNS)-derived EVs has been increasing; however, some skepticism of their importance has persisted because many ...
David R. Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey N. Savas   +3 more
doaj   +1 more source

The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]

, 2015
Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G., Callif, Ben L., Coley, Denise M., Kramer, Audra A., Lerch, Jessica K., Simpson, Matthew T., Thiel, Laura K., Venkatesh, Ishwariya, Wang, Zimei, Winsor, Kristen N.   +9 more
core   +2 more sources

TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex

iScience
Summary: Individuals within the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD) often experience disruptive mental behaviors and sleep-wake disturbances.
Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang   +3 more
doaj   +1 more source

Connecting the Retina to the Brain [PDF]

, 2014
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Work in the laboratory of LE is funded by the BBSRC [BB/J00815X/1] and the R.S. Macdonald Charitable Trust. Research in the
Erskine, Lynda, Herrera, Eloisa
core   +3 more sources

Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience

International Journal of Molecular Sciences, 2020
Quantum dots (QDs) are semiconducting nanoparticles that have been gaining ground in various applications, including the biomedical field, thanks to their unique optical properties.
G. Perini, V. Palmieri, G. Ciasca, M. De Spirito, M. Papi   +4 more
semanticscholar   +1 more source

Predicting odor from molecular structure: a multi-label classification approach

Scientific Reports, 2022
Decoding the factors behind odor perception has long been a challenge in the field of human neuroscience, olfactory research, perfumery, psychology, biology and chemistry.
Kushagra Saini, V. Ramanathan
semanticscholar   +1 more source

Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke

iScience, 2020
Summary: Astrocytic glycogen is an important energy reserve in the brain and is believed to supply fuel during energy crisis. However, the pattern of glycogen metabolism in ischemic stroke and its potential therapeutic impact on neurological outcomes are
Yanhui Cai, Haiyun Guo, Ze Fan, Xinlei Zhang, Di Wu, Wenhong Tang, Tingting Gu, Shiquan Wang, Anqi Yin, Liang Tao, Xunming Ji, Hailong Dong, Yan Li, Lize Xiong   +13 more
doaj   +1 more source

Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine

iScience, 2021
Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng, Huoqing Luo, Zilong Gao, Xiaona Zhu, Yinbo Shen, Yulong Li, Ji Hu, Jiajun Yang   +7 more
doaj   +1 more source