Results 51 to 60 of about 4,835,014 (147)

Mitochondrial methylcytosines as blood-based biomarkers for Alzheimer’s disease dementia prognosis

iScience
Summary: Alzheimer’s Disease Dementia (ADD) prognosis is an unmet medical need. Mitochondrial dysfunction is an early AD etiopathogenic factor. The present study analyzed mitochondrial DNA (mtDNA) methylation patterns in blood samples from patients with ...
Jordi Gascón-Bayarri, Jose Luis Mosquera, Marta Blanch, Pau Martí, Beatriz Fontal, Carla Trapero, Nuria Rojo, Inma Rico, Jaume Campdelacreu, Cristopher Fowler, Simon M. Laws, Adrià Tort-Merino, Raquel Sanchez-Valle, Joan Bello, Juan Fortea, Alberto Lleó, Courosh Mehanian, Russell H. Swerdlow, Ramón Reñé-Ramírez, Marta Barrachina   +19 more
doaj   +1 more source

Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior

iScience
Summary: Mitochondrial division controls the size, distribution, and turnover of this essential organelle. A dynamin-related GTPase, Drp1, drives membrane division as a force-generating mechano-chemical enzyme.
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
doaj   +1 more source

Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior

iScience, 2020
Summary: The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been ...
Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J. Manzoni, Rainer Spanagel   +14 more
doaj   +1 more source

Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina

iScience
Summary: Type 1 cannabinoid receptors (CB1Rs) are expressed in major retinal neurons within the rod-pathway suggesting a role in regulating night visual processing, but the underlying mechanisms remain poorly understood.
Sebastián F. Estay, Camila Morales-Moraga, Alex H. Vielma, Angelina Palacios-Muñoz, Chiayu Q. Chiu, Andrés E. Chávez   +5 more
doaj   +1 more source

Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord

iScience
Summary: Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-induced episodic rhythms in isolated neonatal mouse spinal cords to understand these mechanisms ...
Jonathan J. Milla-Cruz, Adam P. Lognon, Michelle A. Tran, Stephanie A. Di Vito, Carlotta Löer, Anchita Shonak, Matthew J. Broadhead, Gareth B. Miles, Simon A. Sharples, Patrick J. Whelan   +9 more
doaj   +1 more source

Reiterated male-to-female violence disrupts hippocampal estrogen receptor β expression, prompting anxiety-like behavior

iScience
Summary: Intimate partner violence (IPV) is a significant public health concern whose neurological/behavioral sequelae remain to be mechanistically explained.
Jacopo Agrimi, Lucia Bernardele, Naeem Sbaiti, Marco Brondi, Donato D’Angelo, Marta Canato, Ivan Marchionni, Christian U. Oeing, Giussy Barbara, Beatrice Vignoli, Marco Canossa, Nina Kaludercic, Gaya Spolverato, Anna Raffaello, Claudia Lodovichi, Marco Dal Maschio, Nazareno Paolocci   +16 more
doaj   +1 more source

Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning

iScience
Summary: Understanding the adaptability of the motor cortex in response to bilateral motor tasks is crucial for advancing our knowledge of neural plasticity and motor learning.
Jiawei Han, Ruixue Wang, Minmin Wang, Zhihua Yu, Liang Zhu, Jianmin Zhang, Junming Zhu, Shaomin Zhang, Wang Xi, Hemmings Wu   +9 more
doaj   +1 more source

An evolutionarily conserved role for CTNNB1/β-CATENIN in regulating the development of the corpus callosum

iScience
Summary: The corpus callosum (CC) is a major nerve bundle that connects the two hemispheres of the brain. Dysgenesis of the CC is associated with neurodevelopmental disorders such as the CTNNB1 syndrome.
Arpan Parichha, Debarpita Datta, Amrita Singh, Ishita Talwar, Shreya Yadav, Mahima Bose, Varun Suresh, Špela Miroševič, Nina Žakelj, David Gosar, Damjan Osredkar, Shubha Tole   +11 more
doaj   +1 more source

Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane

iScience, 2018
Summary: Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports ...
Ruth D. Taylor, Martin Heine, Nigel J. Emptage, Laura C. Andreae   +3 more
doaj   +1 more source

Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses

iScience
Summary: Long-term depression (LTD) is an activity-dependent decrease in synaptic strength. This state initiates either a re-potentiation or a loss, aka pruning, of the synapse within hours to days following its induction.
Côme Camus, Léa Leval, Viviana Villicana-Munoz, Sarka Jelinkova, Benjamin Compans, Frédéric Gambino, Etienne Herzog, Daniel Choquet, Eric Hosy   +8 more
doaj   +1 more source