Results 51 to 60 of about 4,441,106 (313)
The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. [PDF]
, 2015 The neural activity patterns of suprachiasmatic nucleus (SCN) neurons are dynamically regulated throughout the circadian cycle with highest levels of spontaneous action potentials during the day.
Block, Gene D +2 more
core +1 more source
Predicting odor from molecular structure: a multi-label classification approach
Scientific Reports, 2022 Decoding the factors behind odor perception has long been a challenge in the field of human neuroscience, olfactory research, perfumery, psychology, biology and chemistry.
Kushagra Saini, V. Ramanathan
semanticscholar +1 more source
Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity
iScienceSummary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects
Lars Binkle-Ladisch +14 more
doaj +1 more source
Unravelling the Potential of Graphene Quantum Dots in Biomedicine and Neuroscience
International Journal of Molecular Sciences, 2020 Quantum dots (QDs) are semiconducting nanoparticles that have been gaining ground in various applications, including the biomedical field, thanks to their unique optical properties.
G. Perini +4 more
semanticscholar +1 more source
Connecting the Retina to the Brain [PDF]
, 2014 The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Work in the laboratory of LE is funded by the BBSRC [BB/J00815X/1] and the R.S. Macdonald Charitable Trust. Research in the
Erskine, Lynda, Herrera, Eloisa
core +3 more sources
iScience, 2023 Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen +6 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Memory rescue and learning in synaptic impaired neuronal circuits
iScience, 2023 Summary: Neuronal impairment is a characteristic of Alzheimer’s disease (AD), but its effect on neural activity dynamics underlying memory deficits is unclear.
Kwan Tung Li, Daoyun Ji, Changsong Zhou
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
iScienceSummary: Synaptic structural plasticity, the expansion of dendritic spines in response to synaptic stimulation, is essential for experience-dependent plasticity and is driven by branched actin polymerization. The WAVE regulatory complex (WRC) is confined
Belal Shohayeb +7 more
doaj +1 more source