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Results 91 to 100 of about 1,086 (210)

Dynamic Polydisulfide Latex via Emulsion Ring‐Opening Polymerization of Cyclodisulfides

Journal of Polymer Science, EarlyView.
A polydisulfide latex with a high molar mass was achieved by emulsion polymerization process starting from a dithiol. The mechanism reveals an entropy‐driven ring‐opening polymerization involving disulfide macrocycle intermediates. The polydisulfide particles can be degraded by thiol‐disulfide exchange, and the disulfide fragments can be reengaged in a
Sandric Afonso +5 more
wiley +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, EarlyView.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang +13 more
wiley +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang +5 more
wiley +1 more source

Papain-like cysteine proteases in Nicotiana benthamiana: gene family members and their potential implications in recombinant protein expression

Frontiers in Plant Science
IntroductionPapain-like cysteine proteases (PLCPs), characterized by a conserved cysteine residue at their active sites, play crucial roles in plant growth, development, and responses to biotic and abiotic stresses.
Yalun Yang +17 more
doaj +1 more source

Molecular Pharming–Produktion von Biopharmazeutika in Pflanzen

BIOspektrum
AbstractThe moss Physcomitrella is a promising production platform for green biopharmaceuticals. To further increase production yields of this platform, we identified terminator sequences to be used in future applications. In addition, we investigated which attributes make a terminator a good choice for biomanufacturing.
Niederau, Paul Alexander, Reski, Ralf
openaire +2 more sources

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng +16 more
wiley +1 more source

Analysis of the aspartic protease gene family in Nicotiana benthamiana and its application in recombinant protein expression

Frontiers in Plant Science
IntroductionAspartic proteases (APs) play crucial roles in plant growth, stress responses, and protein metabolism. However, endogenous APs in Nicotiana benthamiana, a key plant molecular farming platform, pose a significant challenge by degrading ...
Yu’e Li +17 more
doaj +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

Allergy, EarlyView.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas +128 more
wiley +1 more source

CRISPR/Cas9-based programmable genome editing in chickens: concepts, applications and regulatory issues

Frontiers in Genome Editing
The advent of genetics, molecular biology, and genome sequencing has rapidly accelerated the development of elite genetic lines across various species, including poultry.
Gautham Kolluri +7 more
doaj +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh +7 more
wiley +1 more source

3. good health
molecular farming
recombinant proteins

humans
biotechnology
plants, genetically modified

2. zero hunger
plants
animals