Results 81 to 90 of about 1,086 (210)

Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story [PDF]

Biotechnology Letters, 2015
This short commentary examines the factors that led to Food and Drug Administration's approval of the first plant-derived biologic.In 2012, the first plant-derived protein pharmaceutical (biologic) was approved for commercial use in humans. The product, a recombinant form of human β-glucocerebrosidase marketed as ELELYSO, was developed by Protalix ...
openaire   +2 more sources

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Plant Molecular Pharming Techno-Economic and Virus-Based Nanomaterial Approaches to Limited Resource Recombinant Protein Manufacturing [PDF]

, 2022
Plants represent a set of richly diverse and genetically tractable sources for high-value natural and recombinant products that can be used to support human health and industry.
McNulty, Matthew
core  

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters

Scientific Reports
Newly emerging SARS-CoV-2 variants of concern (VOCs) continue to drive COVID-19 waves and are typically associated with immune escape and increased resistance to current therapeutics including monoclonal antibodies. By contrast, VOCs still display strong
Esther Föderl-Höbenreich, Shiva Izadi, Lara Hofacker, Nikolaus F. Kienzl, Alexandra Castilho, Richard Strasser, Ferran Tarrés-Freixas, Guillermo Cantero, Núria Roca, Mònica Pérez, Cristina Lorca-Oró, Carla Usai, Joaquim Segalés, Júlia Vergara-Alert, Lukas Mach, Kurt Zatloukal   +15 more
doaj   +1 more source

Response of Soil Fungal Communities to the Alpine Steppe Degradation Gradient

Land Degradation &Development, EarlyView.
ABSTRACT The degradation of alpine steppe on the Qinghai‐Tibet Plateau has become a critical ecological security issue. Soil fungi, as core regulators of grassland ecosystem functioning, play a pivotal role in mediating the feedback between degradation and soil ecological processes.
Xiaoyun Wang, Guoying Zhou, Yuanming Xiao, Wenying Wang, Xinyu Yang, Jinrong Liu   +5 more
wiley   +1 more source

Development of an African horse sickness VP6 DIVA diagnostic ELISA

Virology Journal
Background African horse sickness (AHS) is a severe, noncontagious disease of equines caused by the African horse sickness virus (AHSV). The virus has nine serotypes and is transmitted by the Culicoides midge. AHS is endemic in South Africa and other sub-
Munyaradzi Tinarwo, Susan J. Dennis, Inga I. Hitzeroth, Ann E. Meyers, Edward P. Rybicki, Sandiswa Mbewana   +5 more
doaj   +1 more source

Iron/Manganese Oxide‐Bound Nitrogen Suppresses Microbial Mediated Nitrate Reduction in Soil

Land Degradation &Development, EarlyView.
ABSTRACT Nitrogen cycling plays a pivotal role in sustaining ecosystem productivity and stability, while the chemical forms of nitrogen in soils critically influence both its efficiency and pathways. In this study, farmland soils from the Anning River Basin—an important watershed in Southwest China—were investigated to examine the regulatory effects of
Yu Cheng, Xuehao Zheng, Miao Yang, Shoujiang Liu   +3 more
wiley   +1 more source

Corrosion Inhibition of S275 Carbon Steel in CO2 Capture Systems Using Monoethanolamine (MEA) Solvent

Materials and Corrosion, EarlyView.
Corrosion inhibitors CuSO4 and NaVO3 achieved up to 98% inhibition efficiency for carbon steel S275 in CO2‐loaded MEA solvent, reducing corrosion rates to 9.4 µm/year—outperforming costly stainless steel SS 316 L at a fraction of the cost. ABSTRACT Corrosion in CO2 capture units significantly impacts safety and costs.
Eleni Lamprou, Fani Stergioudi, Georgios Skordaris, Nikolaos Michailidis, Evie Nessi, Athanasios I. Papadopoulos, Panagiotis Seferlis   +6 more
wiley   +1 more source

Administration of Schwann Cell‐Like Cells Differentiated From Tonsil‐Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration by Inducing Macrophage Polarization in a Chronic Constriction Injury Model

Muscle &Nerve, EarlyView.
TMSC‐SCs were mixed with fibrin adhesive and administered into the sciatic nerve of CCI rats, and nerve conduction studies and histopathological observations confirmed the regeneration of the peripheral nerve and gastrocnemius muscle. In addition, the expression of M1 and M2 macrophage markers was observed after the administration of TMSC‐SCs. ABSTRACT
Yu Hwa Nam, Ji‐Sup Kim, Yoonji Yum, Juhee Yoon, Youbeen Cho, Jaeseung Lim, Saeyoung Park, Sung‐Chul Jung   +7 more
wiley   +1 more source