Results 61 to 70 of about 1,086 (210)

Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies [PDF]

, 2022
S.583-590This report describes the stable expression of a medically important antibody in the staple cereal crops rice and wheat. We successfully expressed a single-chain Fv antibody (ScFvT84.66) against carcinoembryonic antigen (CEA), a well ...
Christou, P., Torres, E., Stöger, E., Drossard, J., Fischer, R., Vaquero, C., Williams, S., Keen, D., Sack, M., Perrin, Y., Nicholson, L.   +10 more
core   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Donor–Acceptor Covalent Organic Framework Enables Ambipolar Charge Storage in Aluminum‐Ion Energy Storage

Advanced Energy Materials, EarlyView.
A donor–acceptor covalent organic framework is designed as an ambipolar cathode for aluminum‐ion energy storage. The crystalline, microporous architecture enables intrinsic charge transport without conductive additives. Multi‐electron redox activity at donor and acceptor sites supports high capacity, excellent stability, and efficient reversible ...
Cataldo Valentini, Verónica Montes‐García, Wojciech Kukułka, Saira Sarwar, Michał Bielejewski, Mateusz Wlazło, Rossella Greco, Viktorija Pankratova, Ignacio Pérez‐Juste, Dawid Pakulski, Paolo Samorì, Artur Ciesielski   +11 more
wiley   +1 more source

Plant molecular pharming (PMP) [PDF]

, 2018
Biljke se od davnina koriste za liječenje raznih bolesti. Osim klasičnih načina sinteze lijekova pomoću bakterija, kvasaca i uzgoja u kulturi životinjskih stanica, u današnje vrijeme se razmatra i mogućnost uzgoja genetski modificiranih biljaka koje ...
Ćaleta, Anna
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Molecular pharming in plants and plant cell cultures: a great future ahead?

Pharmaceutical Bioprocessing, 2014
Plant biotechnology may not be a familiar concept to the general public, but it is a rapidly developing field of research that involves the use of plants, plant tissues and plant cell cultures to make or modify products and processes. The versatility of plants and plant cells can be harnessed to produce diverse products, including valuable proteins ...
Häkkinen, Suvi T., Schillberg, Stefan, Ritala, Anneli   +3 more
openaire   +2 more sources

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source

Seeds as a Production System for Molecular Pharming Applications: Status and Prospects

Current Pharmaceutical Design, 2013
The production of recombinant proteins in seeds is achieved by driving transgene expression using promoters and protein targeting sequences derived from genes encoding abundant seed storage proteins. This approach is advantageous because high yields, stability and containment are conferred by the accumulation of recombinant proteins in specialized ...
Sabalza Gallués, Maite, Vamvaka, Evangelia, Christou, Paul, Capell Capell, Teresa   +3 more
openaire   +3 more sources

HLA‐B*15:21 carrier status is a susceptibility factor of carbamazepine‐induced nonimmediate cutaneous adverse reactions in HLA‐B*15:02‐negative patients: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
After HLA‐B*15:02 screening, the residual risk of carbamazepine‐induced nonimmediate cutaneous adverse reactions is 0.059. Among these HLA‐B*15:02‐negative cases, HLA‐B*15:11 and HLA‐B*15:21 carrier status significantly increases the risk of carbamazepine‐induced nonimmediate cADR.
Warit Ruanglertboon, Chutima Seree‐aphinan, Antida Sangiemchoey, Khwanchanok Kaewpiboon, Taweesak Maneerot, Oradawan Plong‐on, Pornsiri Sangmanee, Punthipa Nichanon, Jariya Khayman, Jiraphan Manee, Areerat Hnoonual, Kanoot Jaruthamsophon   +11 more
wiley   +1 more source

Shape‐directed formation of T8/T6 Zn–siloxane clusters and their deep‐UV shielding properties

Bulletin of the Korean Chemical Society, EarlyView.
The shape and conformational characteristics of silane substituents direct the assembly of Zn–siloxane clusters into conventional T8 or rare T6 siloxane frameworks. Non‐planar cyclic substituents selectively promote T6 formation through steric effects, while the resulting clusters exhibit deep‐ultraviolet absorption and can be processed into ...
Dopil Kim, Min Jeong Park, Purna Chandra Rao, Younghu Son, Sung Hwa Jhung, Minyoung Yoon   +5 more
wiley   +1 more source

Internship Reports and Monograph entitled “Molecular Pharming: an alternative route for the production of recombinant proteins of pharmaceutical interest” [PDF]

, 2023
Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de FarmáciaMolecular Pharming is a biotechnology technique that involves the production of biopharmaceuticals products, including high-value recombinant proteins,
Valente, Edna Pinto
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