Results 51 to 60 of about 1,086 (210)
Prospects of mushroom molecular pharming R&D and market potential [PDF]
, 2012 菇菌產業在世界各國均屬高產值精緻農業，也是少數市場需求能以3-10 ％年複合成長率穩定增加的經濟作物。目前在全球的銷售值約達280-300億美元，其生產潛力和市場價值均不容忽視。分子農場在一般係指以植物生產具有醫藥或商業價值之產物的技術平台。菇菌類分子農場是建立在植物分子農場的既有優勢，利用食用菇種富含蛋白質（佔菇體乾重19-35％）、具有微生物生長快速、比植物更接近動物的蛋白質轉譯後修飾作用，且栽培環境條件易於控制等等諸多優勢，成為發展分子農場的最佳平台。就菇菌產業而言，分子農場無論在品種改良 ...
呂映慈, Lyu Y.T.
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Algae-based oral recombinant vaccines
Frontiers in Microbiology, 2014 Recombinant subunit vaccines are some of the safest and most effective vaccines available, but their high cost and the requirement of advanced medical infrastructure for administration make them impractical for many developing world diseases. Plant-based
Elizabeth A Specht, Stephen P Mayfield
doaj +1 more source
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source
Characterization of a novel virus associated with the MVX disease of Agaricus bisporus [PDF]
, 2007 ‘Mushroom Virus X’ (MVX) disease of the cultivated mushroom Agaricus bisporus first arose in UK during the 1990’s. This disease resulted in devastating crop losses in the UK and gradually became more widespread (e.g. Netherlands and Eire).
Maffettone, Eliana
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Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Recent advances on host plants and expression cassettes' structure [PDF]
, 2023 Plant molecular pharming is a promising system to produce important recombinant proteins such as therapeutic antibodies, pharmaceuticals, enzymes, growth factors, and vaccines.
Khaled Moustafa +3 more
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Extracellular peptidase hunting for improvement of protein production in plant cells and roots
Frontiers in Plant Science, 2015 Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve
Jérôme eLallemand +11 more
doaj +1 more source
A simplified techno‐economic model for the molecular pharming of antibodies
Biotechnology and Bioengineering, 2019 AbstractBy the end of 2017, the Food and Drug Administration had approved a total of 77 therapeutic monoclonal antibodies (mAbs), most of which are still manufactured today. Furthermore, global sales of mAbs topped $90 billion in 2017 and are projected to reach $125 billion by 2020.
Pere Mir‐Artigues +6 more
openaire +2 more sources
Advanced Science, EarlyView.Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu +15 more
wiley +1 more source