Results 21 to 30 of about 1,086 (210)

Artificial intelligence-driven systems engineering for next-generation plant-derived biopharmaceuticals

Frontiers in Plant Science, 2023
Recombinant biopharmaceuticals including antigens, antibodies, hormones, cytokines, single-chain variable fragments, and peptides have been used as vaccines, diagnostics and therapeutics.
Subramanian Parthiban, Thandarvalli Vijeesh, Thashanamoorthi Gayathri, Balamurugan Shanmugaraj, Ashutosh Sharma, Ramalingam Sathishkumar   +5 more
doaj   +1 more source

Site-Specific Glycosylation of Recombinant Viral Glycoproteins Produced in Nicotiana benthamiana

Frontiers in Plant Science, 2021
There is an urgent need to establish large scale biopharmaceutical manufacturing capacity in Africa where the infrastructure for biologics production is severely limited. Molecular farming, whereby pharmaceuticals are produced in plants, offers a cheaper
Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Joel D. Allen, Matthew Verbeek, Michiel van Diepen, Michiel van Diepen, Phindile Ximba, Phindile Ximba, Rosamund Chapman, Rosamund Chapman, Ann Meyers, Anna-Lise Williamson, Anna-Lise Williamson, Anna-Lise Williamson, Max Crispin, Edward Rybicki, Edward Rybicki   +18 more
doaj   +1 more source

Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification

Frontiers in Bioengineering and Biotechnology, 2022
The virus-based immunosorbent nanoparticle is a nascent technology being developed to serve as a simple and efficacious agent in biosensing and therapeutic antibody purification.
Matthew J. McNulty, Anton Schwartz, Jesse Delzio, Kalimuthu Karuppanan, Aaron Jacobson, Olivia Hart, Abhaya Dandekar, Anatoli Giritch, Somen Nandi, Somen Nandi, Yuri Gleba, Karen A. McDonald, Karen A. McDonald   +12 more
doaj   +1 more source

Data_Sheet_1_Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9.docx [PDF]

, 2022
Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and ...
Catherine Navarre (679322), Kathrin Göritzer (8750946), Melanie Grandits (434854), Audrey Y-H. Teh (13758124), Clemens Grünwald-Gruber (6007538), Sébastien Mercx (13758121), Julian K-C. Ma (8538096), Rudolf Figl (7337957)   +7 more
core   +1 more source

Enabling Transgenic Plant Cell–Derived Biomedicines with Nanotechnology

Advanced NanoBiomed Research, 2021
Transgenic plants are promising factories for manufacturing pharmaceutical small molecules or proteins safe for human consumption. Eukaryotic plant cells can synthesize proteins with precise posttranslational modifications, but microbes cannot ...
Yee Ting Elaine Chiu, Chung Hang Jonathan Choi   +1 more
doaj   +1 more source

A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov

Molecules, 2021
The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds.
Rambod Abiri, Hazandy Abdul-Hamid, Oksana Sytar, Ramin Abiri, Eduardo Bezerra de Almeida, Surender K. Sharma, Victor P. Bulgakov, Randolph R. J. Arroo, Sonia Malik   +8 more
doaj   +1 more source

Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants

Retrovirology, 2021
Background HIV remains one of the most important health issues worldwide, with almost 40 million people living with HIV. Although patients develop antibodies against the virus, its high mutation rate allows evasion of immune responses.
Catherine M. Moore, Melanie Grandits, Clemens Grünwald-Gruber, Friedrich Altmann, Maria Kotouckova, Audrey Y.-H. Teh, Julian K.-C. Ma   +6 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

The Corn Smut ('Huitlacoche') as a New Platform for Oral Vaccines. [PDF]

PLoS ONE, 2015
The development of new alternative platforms for subunit vaccine production is a priority in the biomedical field. In this study, Ustilago maydis, the causal agent of common corn smut or 'huitlacoche'has been genetically engineered to assess expression ...
Margarita Juárez-Montiel, Andrea Romero-Maldonado, Elizabeth Monreal-Escalante, Alicia Becerra-Flora, Schuyler S Korban, Sergio Rosales-Mendoza, Juan Francisco Jiménez-Bremont   +6 more
doaj   +1 more source

The B1 Domain of Streptococcal Protein G Serves as a Multi-Functional Tag for Recombinant Protein Production in Plants

Frontiers in Plant Science, 2022
Plants have long been considered a cost-effective platform for recombinant production. A recently recognized additional advantage includes the low risk of contamination of human pathogens, such as viruses and bacterial endotoxins. Indeed, a great advance
Shi-Jian Song, Hai-Ping Diao, Byeongho Moon, Areum Yun, Inhwan Hwang   +4 more
doaj   +1 more source