Results 111 to 120 of about 6,842,401 (297)

Grafting enhances drought tolerance by regulating and mobilizing proteome, transcriptome and molecular physiology in okra genotypes. [PDF]

Front Plant Sci, 2023
Razi K, Muneer S.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Ocean warming drives tissue-wide metabolic reprogramming in a fish

iScience
Summary: Ocean warming and marine heatwaves are predicted to have adverse impacts on marine organisms. Yet, knowledge of the molecular mechanisms that underpin successful or failed acclimation to increasing temperatures remains incomplete.
Billy Moore, Shannon McMahon, Michael Izumiyama, Taewoo Ryu, Timothy Ravasi   +4 more
doaj   +1 more source

Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. [PDF]

Acta Physiol (Oxf), 2022
Eriksen MS, Bramham CR.
europepmc   +1 more source

The −20 and −217 Promoter Variants Dominate Differential Angiotensinogen Haplotype Regulation in Angiotensinogen-Expressing Cells

HYPERTENSION, 2007
Matthew E. Dickson, M. Zimmerman, K. Rahmouni, C. Sigmund, Molecular Physiology, Biophysics, R. J, L. A. Carver, R. Facility   +8 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Success in failure: modeling cardiac decompensation in transgenic mice.

Circulation, 1998
W. R. Maclellan, M. D. Schneider, Molecular Physiology, Biophysics, Houston Veterans   +4 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2022
Okahata M, Motomura H, Ohta A, Kuhara A.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source