Results 121 to 130 of about 642,316 (296)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Molecular mechanisms shaping the plant biomass utilization potential in Aspergillus

, 2017
Coordination of the induction of genes encoding extracellular enzymes and sugar uptake systems in fungi are often mediated by transcription factors (TFs).
Sub Molecular Plant Physiology, Kowalczyk, Joanna E, Kowalczyk, Joanna   +2 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Role of Interventional Irisin on Heart Molecular Physiology. [PDF]

Pharmaceuticals (Basel), 2022
Alzoughool F, Al-Zghoul MB, Ghanim BY, Gollob M, Idkaidek N, Qinna NA.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Molecular physiology of pumiliotoxin sequestration in a poison frog. [PDF]

PLoS One, 2022
Alvarez-Buylla A, Payne CY, Vidoudez C, Trauger SA, O'Connell LA.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sweet connections, bZIP transcription factors and the regulation of metabolism in Arabidopsis

, 2009
bZIP transcription factors are part of an intricate signaling network connecting sugar signaling to metabolism (Figure 1.5). Many inputs and components of this system are known, but little is known on the actual function of bZIP transcription factors. In
Hanssen, M.G.M, Molecular Plant Physiology, Dep Biologie   +2 more
core  

Ocean warming drives tissue-wide metabolic reprogramming in a fish

iScience
Summary: Ocean warming and marine heatwaves are predicted to have adverse impacts on marine organisms. Yet, knowledge of the molecular mechanisms that underpin successful or failed acclimation to increasing temperatures remains incomplete.
Billy Moore, Shannon McMahon, Michael Izumiyama, Taewoo Ryu, Timothy Ravasi   +4 more
doaj   +1 more source

Grafting enhances drought tolerance by regulating and mobilizing proteome, transcriptome and molecular physiology in okra genotypes. [PDF]

Front Plant Sci, 2023
Razi K, Muneer S.
europepmc   +1 more source