Results 151 to 160 of about 642,316 (296)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Challenges and advances in systems biology analysis of Bacillus spore physiology; molecular differences between an extreme heat resistant spore forming Bacillus subtilis food isolate and a laboratory strain

, 2011
Bacterial spore formers are prime organisms of concern in the food industry. Spores from the genus Bacillus are extremely stress resistant, most notably exemplified by high thermotolerance. This sometimes allows surviving spores to germinate and grow out
Oomes, S., Beilen, J.van, Andrea O’Brien, Kort, Remco; id_orcid, Suus Oomes, Stanley Brul, de Koster, Chris, Kort, Remco, Caspers, M., van Beilen, J., ter Beek, A., Koster, C.de, Ter Beek, Alex, Caspers, Martien P M, Kort, R., O'Brien, Andrea, Martien Caspers, Smelt, J., Alex Ter Beek, Chris de Koster, Smelt, Jan, de Koster, C., Jan Smelt, Beek, A.ter, O'Brien, A., Johan van Beilen, Brul, S., Brul, Stanley, van Beilen, Johan, Oomes, Suus, Remco Kort   +30 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mechano and chemosensory function of colonic primary afferent fibres in splanchnic and pelvic pathways/ Stuart Matthew Brierley. [PDF]

, 2005
"November 2005"Bibliography: leaves 346-266.366 leaves : ill. (some col.), col. plates ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, Discipline of Physiology ...
Brierley, Stuart Matthew
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Gating of the CIC-1 chloride channel/ Michael Duffield. [PDF]

, 2005
Bibliography: leaves 117-136.vii, 136 leaves : ill. (chiefly col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Physiology ...
Duffield, Michael David
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Molecular Physiology APS Exam

, 2015
Exam paper for second semester: Molecular Physiology APS ...
University of Johannesburg
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Impact of chronic prenatal hypoxia on vascular function during fetal, neonatal and adult life / Sarah Jade Williams. [PDF]

, 2005
"September 2005"Bibliography: pages 162-194.xxi, 194 pages : ill., plates (col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Science, Discipline of Physiology ...
Williams, Sarah Jade
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source