Results 261 to 270 of about 642,316 (296)
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Molecular Physiology of P2X Receptors
Physiological Reviews, 2002P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40–50% identical in amino acid sequence. Each subunit has two transmembrane domains, separated by an extracellular domain (∼280 amino acids). Channels form as multimers of several subunits.
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Molecular characteristics and physiology of microsporidia
Microbes and Infection, 2001A survey of the molecular features of microsporidia is presented which attempts to comment on unresolved questions concerning the physiology of these amitochondrial intracellular parasites. Various transports of host-derived molecules can be predicted and trehalose appears as a potential reserve of glucose for energy metabolism.
G, Méténier, C P, Vivarès
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Molecular Physiology of the WNK Kinases
Annual Review of Physiology, 2008Mutations in the serine-threonine kinases WNK1 and WNK4 cause a Mendelian disease featuring hypertension and hyperkalemia. In vitro and in vivo studies have revealed that these proteins are molecular switches that have discrete functional states that impart different effects on downstream ion channels, transporters, and the paracellular pathway. These
Kristopher T, Kahle +2 more
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Molecular mechanism of physiological fibrinolysis
Nature, 1978THE proteolytic enzyme system in blood that is predominantly responsible for removal of fibrin deposits, is called the fibrinolytic system. This system consists of three main components: the proenzyme plasminogen, which can be activated by limited proteolysis to the proteolytic enzyme plasmin; plasminogen activators, the most important of which ...
B, Wiman, D, Collen
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Omics and the molecular exercise physiology
2020Exercise is a well-known non-pharmacologic agent used to prevent and treat a wide range of pathologic conditions such as metabolic and cardiovascular disease. In this sense, the classic field of exercise physiology has determined the main theoretical and practical bases of physiologic adaptations in response to exercise.
Cpc, Gomes +3 more
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Physiologic and molecular biology of erythropoietin
Medical Oncology and Tumor Pharmacotherapy, 1986The gene for erythropoietin, the first growth and differentiation factor to be identified, has now been cloned and a recombinant erythropoietin is ready for clinical trials. This molecular achievement has also led to the identification of its mRNA in liver and especially in kidney tissue and here in the extra glomerular fraction.
A J, Erslev, J, Caro
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Molecular physiology of aquaporins in plants
2002In plants, membrane channels of the major intrinsic protein (MIP) super-family exhibit a high diversity with, for instance, 35 homologues in the model species Arabidopsis thaliana. As has been found in other organisms, plant MIPs function as membrane channels permeable to water (aquaporins) and in some cases to small nonelectrolytes.
Maurel, Christophe +7 more
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Molecular Physiology of Cardiac Repolarization
Physiological Reviews, 2005The heart is a rhythmic electromechanical pump, the functioning of which depends on action potential generation and propagation, followed by relaxation and a period of refractoriness until the next impulse is generated. Myocardial action potentials reflect the sequential activation and inactivation of inward (Na+and Ca2+) and outward (K+) current ...
Jeanne M, Nerbonne, Robert S, Kass
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Molecular sensory physiology ofEuglena
Die Naturwissenschaften, 1976After a short description of the motile physiology of Euglena gracilis the responses to light stimulation are analyzed and a new nomenclature is proposed concerning flagellar motility variations. A discussion follows about the characteristics of the photoreceptive system of Euglena and about the flavinic nature of its phototactic pigments.
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Molecular Physiology of Urate Transport
Physiology, 2005Humans excrete uric acid as the final breakdown product of unwanted purine nucleotides. Urate scavenges potential harmful radicals in our body. However, in conjunction with genetic or environmental (especially dietary) factors, urate may cause gout, nephrolitiasis, hypertension, and vascular disease.
Matthias A, Hediger +3 more
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