Results 91 to 100 of about 264,869 (298)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
From Precursors to Pollutants: Some Advances in Combustion Chemistry Diagnostics
Eurasian Chemico-Technological Journal, 2014 The present assessment and prediction of potential pollutant emissions from combustion systems often rely on dedicated combustion models. Their validation depends on the critical examination of the relevant chemical reaction pathways.
J. Krüger +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Beyond resolution: AI-powered subcellular bioimaging for next-generation smart diagnostics
Biosensors and Bioelectronics: XThe dynamic landscape of subcellular imaging is entering a transformative era fueled by synergistic advances in fluorescent probe design and artificial intelligence (AI).
Andrés F. Luis-Robles +2 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Chemical modification of 2D materials using molecules and assemblies of molecules
Advances in Physics: X, 2019 In this article, we discuss the recent progress on controlled structural modification of 2D materials by means of molecular functionalization, with a focus on scanning probe microscopy techniques for their characterization.
Lakshya Daukiya +2 more
doaj +1 more source
Molecular structure of agarose chains in thermoreversible hydrogels revealed by means of a fluorescent probe technique [PDF]
, 2005 Hideyuki Itagaki +3 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
N-fluoroacetyl-α-
, 1971 P. W. Kent, Raymond A. Dwek
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