Results 141 to 150 of about 604,365 (268)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Bitopic A₃ Adenosine Receptor Molecular Probes: Positive Allosteric Modulation and Noncanonical Activation. [PDF]

J Med Chem
Kurma SH, Pavan M, Wan TC, Pradhan B, López-Cano M, Ciruela F, Gao ZG, Auchampach JA, Jacobson KA.   +8 more
europepmc   +1 more source

Polymeric Nanoparticles with Embedded Eu(III) Complexes as Molecular Probes for Temperature Sensing. [PDF]

Molecules, 2022
Kuznetsov KM, Baigildin VA, Solomatina AI, Galenko EE, Khlebnikov AF, Sokolov VV, Tunik SP, Shakirova JR.   +7 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Identifying Molecular Probes for Fluorescence-Guided Surgery in Neuroblastoma: A Systematic Review. [PDF]

Children (Basel)
Hennessy M, Neville JJ, Privitera L, Sedgwick A, Anderson J, Giuliani S.   +5 more
europepmc   +1 more source

Pacific Blue-Taxoids as Fluorescent Molecular Probes of Microtubules. [PDF]

Methods Mol Biol, 2022
Andres AE, Rane D, Peterson BR.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Safirinium Fluorescent "Click" Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging. [PDF]

Molecules
Kasza P, Szafrański PW, Fedorowicz J, Krzysztofiak F, Pociecha K, Wójcik-Pszczoła K, Koczurkiewicz-Adamczyk P, Kępczynski M, Sączewski J, Zajdel P, Cegła M.   +10 more
europepmc   +1 more source

Recent developments on the application of molecular probes in multiple myeloma: Beyond [¹⁸F]FDG. [PDF]

Front Bioeng Biotechnol, 2022
Zhang S, Shang J, Ye W, Zhao T, Xu H, Zeng H, Wang L.   +6 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source