Results 151 to 160 of about 604,365 (268)

From Latent Manifolds to Targeted Molecular Probes: An Interpretable, Kinome-Scale Generative Machine Learning Framework for Family-Based Kinase Ligand Design. [PDF]

Biomolecules
Verkhivker G, Kassab R, Krishnan K.
europepmc   +1 more source

Molecular probes for cellular imaging of post-translational proteoforms. [PDF]

RSC Chem Biol, 2022
Suraritdechachai S, Lakkanasirorat B, Uttamapinant C.   +2 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Redefining Molecular Probes for Monitoring Subcellular Environment: A Perspective. [PDF]

Anal Chem
García S, Carmona-Santiago G, Jiménez-Sánchez A.   +2 more
europepmc   +1 more source

De Novo Development of Mitochondria-Targeted Molecular Probes Targeting Pink1. [PDF]

Int J Mol Sci, 2022
Ben-Uliel SF, Zoabi FH, Slavin M, Sibony-Benyamini H, Kalisman N, Qvit N.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design. [PDF]

Front Chem, 2022
Wang Y, Lin Q, Shi H, Cheng D.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Application of rare earth elements in dual-modality molecular probes. [PDF]

RSC Adv
He JF, Yang WW, Quan WX, Yang YC, Zhang Z, Luo QY.   +5 more
europepmc   +1 more source