Results 21 to 30 of about 596,923 (316)

One-Pot Difunctionalization of Aryldiazonium Salts for Synthesis of para-Azophenols

Frontiers in Chemistry, 2022
A novel difunctionalization of aryldiazonium salts was realized for the one-step generation of symmetric and asymmetric p-azophenols. This approach is proceeded by the sequentially regioselective aromatic C-O and C-N bond construction under mild reaction
Zhenhua Liu, Yang Fang, Yi Liu, Wei Fu, Xingxing Gan, Wen Gao, Bo Tang   +6 more
doaj   +1 more source

Molecular Probe Data Base (MPDB) [PDF]

Nucleic Acids Research, 1997
Molecular Probe Data Base contains detailed information on synthetic oligonucleotides with a sequence of up to 100 nucleotides. This database prevalently contains information related to human oligonucleotides used in diagnostics. Molecular Probe Data Base has been made available on-line through the Internet by means of Network Information Retrieval ...
M G, Campi, M, Castoldi, P, Romano, E, Thüroff, M A, Manniello, B, Iannotta, G, Rondanina, T, Ruzzon, L, Santi   +8 more
openaire   +2 more sources

A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

Nature Communications, 2018
Photodynamic therapy is usually ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Here, the authors design a biomimetic nanoreactor which can convert nutriment glucose into toxic singlet oxygen via ...
Zhengze Yu, Ping Zhou, Wei Pan, Na Li, Bo Tang   +4 more
doaj   +1 more source

Molecular Probes of Spermatozoan Structures [PDF]

Proceedings of the National Academy of Sciences, 1971
Several methods have been devised for the isolation and labeling of structural components of spermatozoa. Rodent spermatozoa were cleaved rapidly and specifically at the junction of the heads and tails by treatment with various proteases, and the separate components were isolated by density-gradient centrifugation.
G M, Edelman, C F, Millette
openaire   +2 more sources

Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Molecules, 2023
Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-
Qing Shi, Meiqi Xu, Zhijian Kang, Manjie Zhang, Yakun Luo   +4 more
doaj   +1 more source

Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme

Nature Communications
In enzymatic catalysis, the redox site and Lewis acid are the two main roles played by metal to assist amino acids. However, the reported enzyme mimics only focus on the redox-active metal as redox site, while the redox-inert metal as Lewis acid has, to ...
Haibin Si, Dexin Du, Chengcheng Jiao, Yan Sun, Lu Li, Bo Tang   +5 more
doaj   +1 more source

Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

Nature Communications, 2018
Capsaicin prevents atherosclerotic plaque formation by activating TRPV1 cation channels, but its toxicity precludes its use in clinical settings.
Wen Gao, Yuhui Sun, Michelle Cai, Yujie Zhao, Wenhua Cao, Zhenhua Liu, Guanwei Cui, Bo Tang   +7 more
doaj   +1 more source

T-cell infiltration in the central nervous system and their association with brain calcification in Slc20a2-deficient mice

Frontiers in Molecular Neuroscience, 2023
Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial calcification along the microvessels or inside neuronal cells in the basal ganglia, thalamus, and ...
Yi Zhang, Yi Zhang, Yaqiong Ren, Yueni Zhang, Yueni Zhang, Ying Li, Ying Li, Chao Xu, Chao Xu, Ziyue Peng, Ziyue Peng, Ying Jia, Ying Jia, Shupei Qiao, Shupei Qiao, Zitong Zhang, Zitong Zhang, Lei Shi, Lei Shi   +18 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Tracking interactions between TAMs and CAFs mediated by arginase‐induced proline production during immune evasion of HCC

Aggregate
Synergistic changes between tumor‐associated macrophages (TAMs) and cancer‐associated fibroblasts (CAFs) aggravated immune evasion of hepatocellular carcinoma (HCC), however, the underlying molecular mechanisms remain elusive.
Chuanchen Wu, Yuantao Mao, Xinru Qi, Xin Wang, Ping Li, Wen Zhang, Bo Tang   +6 more
doaj   +1 more source