Results 41 to 50 of about 631,116 (314)

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

open access: yes, 2013
Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism.
O'Neill, Paul   +18 more
core   +1 more source

Technical Note: Determination of the metabolically active fraction of benthic foraminifera by means of Fluorescent In Situ Hybridization (FISH) [PDF]

open access: yes, 2011
Benthic foraminifera are an important component of the marine biota, but protocols for investigating their viability and metabolism are still extremely limited.
Negri, Alessandra   +33 more
core   +1 more source

Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/β-catenin axis

open access: yesCellular & Molecular Biology Letters
Circular RNAs (circRNAs) play a crucial role in the initiation and development of cancers. Understanding circRNAs’ functions and molecular mechanisms in tumor development is expected to reveal new diagnostic indicators and therapeutic targets of prostate
Kailai Chen   +10 more
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

Synthesis of molecular probes targeting ER flippases [PDF]

open access: yes, 2018
Most proteins that enter the secretory pathway become glycoproteins, i.e. they are modified by sugars, such as N-glycans. The absence of N-glycans is lethal, and alterations in glycosylation patterns may lead to devastating diseases, including cancer ...
Picca, Giovanni
core  

A Simple Gold Nanoparticle Probes Assay for Identification of Mycobacterium Tuberculosis and Mycobacterium Tuberculosis Complex from Clinical Specimens

open access: yes, 2011
We had previously developed a nested polymerase chain reaction (PCR)- immunochromatography test (ICT) for identification of Mycobacterium tuberculosis (MTB) and differentiation of MTB from other members of M.
蘇伯琦;洪育芝;張凱誌;王振源;薛博仁;莊淳宇;陸嘉真;賴信志   +1 more
core   +1 more source

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer

open access: yesMolecular Cancer
Background Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RNAs (circRNAs) have emerged as key regulators of the metastasis of various cancers.
Xiang Pan   +10 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Probing molecular motion by NMR

open access: yesCurrent Opinion in Structural Biology, 1997
Recently developed solution NMR methods for measuring 2H, 13C, and 15N spin relaxation, coupled with biosynthetic isotopic enrichment, permit the characterization of backbone and sidechain dynamical properties of proteins on picosecond/nanosecond and microsecond/millisecond timescales. Theoretical interpretations of the relaxation data provide insights
openaire   +2 more sources

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters   +17 more
wiley   +1 more source

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