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Circulation Research, 2006 See related articles, pages 501–509 and 510–519 Physiology is an old (some today may consider it an ancient) discipline. However, physiology is, at its core, the discipline that merges structure and function in biological organisms. Over the past 30 years, as technology has advanced, the discipline has gravitated to smaller and smaller systems ...
James K. Bubien, Dale J. Benos
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
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Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel +15 more
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Photocatalytic four-component reaction to access covalent organic frameworks for photocatalysis
Nature CommunicationsPhotocatalytic four-component reaction is an efficient and environmentally friendly synthetic strategy known for its step economy and operational simplicity, enabling the preparation of diverse organic products.
Cheng-Juan Wu +8 more
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Nano ResearchElectrochemical CO2 reduction reaction (CO2RR) to formate presents a technoeconomic route for CO2 utilization under mild conditions, yet practical implementation is constrained by the high energy consumption (> 90% of total input) of the anodic oxygen ...
Zhuangzhuang Ren +8 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Fluorescent Imaging for Cysteine Detection In Vivo with High Selectivity
ChemistryOpen, 2019 As an essential amino acid, cysteine is involved in various biosynthetic and metabolic processes, such as protein synthesis, hormone synthesis, and redox homeostatic maintenance. Inordinate cysteine levels are often associated with serious diseases. Thus,
Zhuwen Duan +7 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
International Journal of Electrochemical Science, 2017 A sensitive electrochemical immunosensor was reported with signal amplification by biometallization of Ni-P. In this strategy, the primary antibody probes were immobilized on the aminated glass surface to bond the target antigen.
Xinli Guo +6 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu +7 more
wiley +1 more source