Results 61 to 70 of about 631,116 (314)

A Pan-GTPase Inhibitor as a Molecular Probe

PLOS ONE, 2015
Overactive GTPases have often been linked to human diseases. The available inhibitors are limited and have not progressed far in clinical trials. We report here a first-in-class small molecule pan-GTPase inhibitor discovered from a high throughput screening campaign. The compound CID1067700 inhibits multiple GTPases in biochemical, cellular protein and
Lin Hong, Yuna Guo, Soumik BasuRay, Jacob O Agola, Elsa Romero, Denise S Simpson, Chad E Schroeder, Peter Simons, Anna Waller, Matthew Garcia, Mark Carter, Oleg Ursu, Kristine Gouveia, Jennifer E Golden, Jeffrey Aubé, Angela Wandinger-Ness, Larry A Sklar   +16 more
openaire   +4 more sources

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source

Photocatalytic four-component reaction to access covalent organic frameworks for photocatalysis

Nature Communications
Photocatalytic four-component reaction is an efficient and environmentally friendly synthetic strategy known for its step economy and operational simplicity, enabling the preparation of diverse organic products.
Cheng-Juan Wu, Ting-Rui Li, Wen-Jing Liang, Hao-Jia Wang, Li-Jing Niu, Jianzhong Fan, Jing-Lan Kan, Yan Geng, Yu-Bin Dong   +8 more
doaj   +1 more source

T-cell infiltration in the central nervous system and their association with brain calcification in Slc20a2-deficient mice

Frontiers in Molecular Neuroscience, 2023
Primary familial brain calcification (PFBC) is a rare neurodegenerative and neuropsychiatric disorder characterized by bilateral symmetric intracranial calcification along the microvessels or inside neuronal cells in the basal ganglia, thalamus, and ...
Yi Zhang, Yi Zhang, Yaqiong Ren, Yueni Zhang, Yueni Zhang, Ying Li, Ying Li, Chao Xu, Chao Xu, Ziyue Peng, Ziyue Peng, Ying Jia, Ying Jia, Shupei Qiao, Shupei Qiao, Zitong Zhang, Zitong Zhang, Lei Shi, Lei Shi   +18 more
doaj   +1 more source

Development and application of DNA molecular probes

AIMS Bioengineering, 2017
The development of DNA probes started from 1950's for diagnostic purposes and it is still growing. DNA probes are applied in several fields such as food, medical, veterinary, environment and security, with the aim of prevention, diagnosis and treatment.
Vizzini, Priya, IACUMIN, Lucilla, COMI, Giuseppe, MANZANO, Marisa   +3 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Signal-amplified Immunoassay Based on Biometallization of Palladium Nanoparticles and Nickel-Phosphorus Enhancement

International Journal of Electrochemical Science, 2017
A sensitive electrochemical immunosensor was reported with signal amplification by biometallization of Ni-P. In this strategy, the primary antibody probes were immobilized on the aminated glass surface to bond the target antigen.
Xinli Guo, Ping Zhang, Xinliang Liu, Na Zhang, Meihua Jiang, Qi Kang, Dazhong Shen   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modular synthesis of biologically active phosphatidic acid probes using click chemistry

, 2009
Phosphatidic acid (PA) is an important signaling lipid that plays roles in a range of biological processes including both physiological and pathophysiological events.
Stahelin, Robert V., Gong, Denghuang, Smith, Matthew D., Sudhahar, Christopher G., Best, Michael D.   +4 more
core   +1 more source

Bioresponsive probes for molecular imaging: concepts and in vivo applications [PDF]

, 2015
Contains fulltext : 154651.pdf (Publisher’s version ) (Open Access)Molecular imaging is a powerful tool to visualize and characterize biological processes at the cellular and molecular level in vivo. In most molecular imaging approaches,
Duijnhoven, S.M. van, Sander M. J. van Duijnhoven, Robillard, MS Marc, Langereis, S Sander, Grull, H., van Duijnhoven, S.M.J., Robillard, M.S., Langereis, S., Grüll, H Holger, Duijnhoven, SMJ Sander van, Sander Langereis, Holger Grüll, Marc S. Robillard   +12 more
core   +1 more source