Results 71 to 80 of about 631,116 (314)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dual-Targeted Molecular Probes for Cancer Imaging

, 2010
Molecular imaging provides a powerful tool for early disease detection, characterization, and real-time monitoring of therapeutic responses. Central to molecular imaging is the development of imaging probes.
Liu, Zhaofei, Wang, Fan, Zhaofei Liu, Fan Wang   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Molecular tools for a molecular medicine: analyzing genes, transcripts and proteins using padlock and proximity probes

, 2004
Procedures and reagents are needed to specifically detect all the macromolecules that are being identified in the course of genome projects. We discuss how this challenge may be met using a set of ligation-based reagents termed padlock probes and ...
Simon Fredriksson, Söderberg, Ola,, Olle Ericsson, Edith Schallmeiner, Johan Banér, Ericsson, Olle,, Ulf Landegren, Fredriksson, Simon,, Schallmeiner, Edith,, Mats Gullberg, Ola Söderberg, Jarvius, Jonas,, Dahl, Fredrik,, Jonas Jarvius, Banér, Johan,, Fredrik Dahl, Gustafsdottir, Sigrun,, Johan Stenberg, Nilsson, Mats,, Stenberg, Johan,, Sigrun Gustafsdottir, Landegren, Ulf,, Mats Nilsson, Gullberg, Mats,   +23 more
core   +1 more source

BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy

iScience, 2019
Summary: Covalent organic frameworks (COFs), an emerging class of organic porous materials, have attracted intense attention due to their versatile applications.
Qun Guan, Dan-Dan Fu, Yan-An Li, Xiang-Mei Kong, Zhi-Yuan Wei, Wen-Yan Li, Shao-Jun Zhang, Yu-Bin Dong   +7 more
doaj   +1 more source

Impact of refractive index increment on the determination of molecular weight of hyaluronic acid by muti-angle laser light-scattering technique

Scientific Reports, 2020
Hyaluronic acid (HA) is applied in a number of medical applications and HA of different molecular weight (Mw) are used in different pharmaceutical preparations.
Ying Han, Dejie Li, Deqiang Li, Wenwen Chen, Shu’e Mu, Yuqin Chen, Jinling Chai   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Physico-chemical properties of ionic-liquid water mixtures [PDF]

, 2011
In order for Ionic Liquids (ILs) to be utilized to their full potential, it is necessary to have a complete understanding of their physical properties, including phase transitions temperatures1. We have previously reported into the extent of structuring
Coleman, Simon, Gallagher, Simon, Fraser, Kevin J., Diamond, Dermot, Byrne, Robert   +4 more
core  

In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux

Advanced Science
Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and the activation of protective mitochondrial autophagy severely restricts the ...
Yulin Lv, Benli Song, Guang Yang, Yuting Wang, Zeyu Wu, Minggui Si, Zongzheng Yang, Huilin Chen, Chen Liu, Min Li, Yinshi Zhang, Zengying Qiao, Lu Wang, Wanhai Xu   +13 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source