Results 71 to 80 of about 604,365 (268)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Nature CommunicationsThe exploration of stable and functional linkages by multicomponent reactions to enrich the stability and diversity of covalent organic frameworks (COFs) and to broaden their potential applications is of fundamental significance to the development of ...
Ke-Hui Xie +9 more
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Frontiers in ImmunologyBackgroundObesity is a metabolic and chronic inflammatory disease involving genetic and environmental factors. This study aimed to investigate the causal relationship among gut microbiota abundance, plasma metabolomics, peripheral cell (blood and immune ...
Ying Li +17 more
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Nanomaterials, 2019 A label-free electrochemical aptasensor was fabricated to sensitively determine malachite green (MG) based on Au nanoparticles/graphene quantum dots-tungsten disulfide nanosheet composite film modified glassy carbon electrode (AuNPs/GQDs-WS2/GCE).
Qianqian Wang +3 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
International Journal of Electrochemical Science, 2017 A silver hexacyanoferrate-graphene hybrid modified glassy carbon electrode is put forward in sensing of uric acid (UA) and dopamine (DA) in this work.
Fenghua Zhang +3 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Nature CommunicationsMyocardial ischemia (MI), caused by insufficient blood supply, is a pathological condition where cardiomyocytes lack oxygen and energy supply. Herein, we developed a natural photosynthetic system (HCU) consisting of chlorella pyrenoidosa (C.
Yuan Cheng +7 more
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International Journal of Electrochemical Science, 2017 The determination of cancer biomarkers plays an important role in early cancer screening and disease diagnosis. Herein, we designed a sandwiched “signal on” electrochemiluminescence (ECL) immunosensor to alpha fetoprotein (AFP) using gold nanoparticle ...
Jiangru Wang +5 more
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