Results 31 to 40 of about 631,116 (314)

Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme

Nature Communications
In enzymatic catalysis, the redox site and Lewis acid are the two main roles played by metal to assist amino acids. However, the reported enzyme mimics only focus on the redox-active metal as redox site, while the redox-inert metal as Lewis acid has, to ...
Haibin Si, Dexin Du, Chengcheng Jiao, Yan Sun, Lu Li, Bo Tang   +5 more
doaj   +1 more source

One-Pot Difunctionalization of Aryldiazonium Salts for Synthesis of para-Azophenols

Frontiers in Chemistry, 2022
A novel difunctionalization of aryldiazonium salts was realized for the one-step generation of symmetric and asymmetric p-azophenols. This approach is proceeded by the sequentially regioselective aromatic C-O and C-N bond construction under mild reaction
Zhenhua Liu, Yang Fang, Yi Liu, Wei Fu, Xingxing Gan, Wen Gao, Bo Tang   +6 more
doaj   +1 more source

Mechanisms and Molecular Probes of Sirtuins

Chemistry & Biology, 2008
Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle, and apoptosis. Sirtuins are associated with a variety of age-associated diseases such as type II diabetes, obesity, and Alzheimer's disease. A thorough understanding of sirtuin chemical mechanisms will aid toward developing novel therapeutics that ...
Smith, Brian C., Hallows, William C., Denu, John M.   +2 more
openaire   +2 more sources

Molecular pH Probes [PDF]

Circulation Research, 2006
See related articles, pages 501–509 and 510–519 Physiology is an old (some today may consider it an ancient) discipline. However, physiology is, at its core, the discipline that merges structure and function in biological organisms. Over the past 30 years, as technology has advanced, the discipline has gravitated to smaller and smaller systems ...
James K. Bubien, Dale J. Benos
openaire   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Tracking interactions between TAMs and CAFs mediated by arginase‐induced proline production during immune evasion of HCC

Aggregate
Synergistic changes between tumor‐associated macrophages (TAMs) and cancer‐associated fibroblasts (CAFs) aggravated immune evasion of hepatocellular carcinoma (HCC), however, the underlying molecular mechanisms remain elusive.
Chuanchen Wu, Yuantao Mao, Xinru Qi, Xin Wang, Ping Li, Wen Zhang, Bo Tang   +6 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

Nature Communications, 2018
Capsaicin prevents atherosclerotic plaque formation by activating TRPV1 cation channels, but its toxicity precludes its use in clinical settings.
Wen Gao, Yuhui Sun, Michelle Cai, Yujie Zhao, Wenhua Cao, Zhenhua Liu, Guanwei Cui, Bo Tang   +7 more
doaj   +1 more source

Metal‐Free B, N co‐Doped Hierarchical Porous Carbon Electrocatalyst with an Excellent O2 Reduction Performance

ChemistryOpen, 2021
Fuel cells have attracted increasing attention due to their low cost, high energy density, low environmental pollution, and abundant raw materials.
Fangxiao Wang, Jianhai Ren, Zihao Zheng, Qiye Liu, Dr. Chun‐yang Zhang   +4 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source