Results 251 to 260 of about 10,169,709 (296)
Some of the next articles are maybe not open access.
Molecular Properties of Lysosomal Glucocerebrosidase
1988In Gaucher disease the membrane-associated lysosomal enzyme glucocerebrosidase is deficient (1). Three clinical phenotypes of Gaucher disease are discriminated: type 1, the adult non-neuronopathic form, type 2, the infantile neuronopathic form and type 3, the juvenile neuronopathic form (1).
van Weely, S. +7 more
openaire +2 more sources
Molecular Similarity and Property Similarity
Current Topics in Medicinal Chemistry, 2004This paper reviews the main efforts undertaken up to date in order to understand, rationalize and apply the similarity principle (similar compounds=>similar properties) as a computational tool in modern drug discovery. The best suited mathematical expression of this classical working hypothesis of medicinal chemistry needs to be carefully chosen (out ...
Frédérique, Barbosa, Dragos, Horvath
openaire +2 more sources
Molecular properties of P2X receptors
Pflügers Archiv - European Journal of Physiology, 2006P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X(1-7)) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range ...
Roberts, Jonathan A. +6 more
openaire +3 more sources
Molecular properties of tunicate DNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract DNA's from primitive chordates, the ascidians (Class Ascidiacea, subphylum Urochordata) have been characterized. Base compositions were inferred from thermal denaturation profiles and analytical CsCl pycnography. Base sequence complexity was estimated for DNA from one species, Ciona intestinalis.
C C, Lambert, C D, Laird
openaire +2 more sources
THE VELOCITY OF SOUND : A MOLECULAR PROPERTY
Nature, 1946THE classical conception of the mechanism of the propagation of sound in gases presents two alternative expressions for the velocity, according as one assume with Newton that the elastic processes are isothermal, or with Laplace that they are adithatic It is well known that experiments show the fatter to be appropriate down to the lowest frequencies at
openaire +2 more sources
Time Reversal and Molecular Properties
Accounts of Chemical Research, 2001Chemists regularly exploit point group symmetry in their analyses of molecular structure and properties but they rarely utilize time reversal symmetry. The time reversal operator T reverses the momenta and spins of all particles in a system and distinguishes properties which are even under T, such as the electric dipole moment, from those that are odd,
L D, Barron, A D, Buckingham
openaire +2 more sources
Optical properties and molecular interactions
Pure and Applied Chemistry, 1974ABSTRACT This paper deals mainly with the modifications of molecular spectra when the density varies as a function of pressure and temperature. It represents a brief survey of some of the work conducted at Bellevue. The main topics covered are: (i) depolarized scattering of light by rare gases, due to anisotropic field fluctuations and atomic ...
openaire +1 more source
Molecular Similarity and Estimation of Molecular Properties
Journal of Chemical Information and Computer Sciences, 1995Subhash C. Basak, Gregory D. Grunwald
openaire +2 more sources
Chymotrypsin: Molecular and catalytic properties
Clinical Biochemistry, 1986A review on the peptide hydrolase chymotrypsin gives some characteristics concerning the structure, specificity, mechanism of activation from its precursor and catalytic activity. Problems of the active sites, allosteric alterations, changes of conformation, different behaviour against types of substrates, and suggested kinetics are shown in some ...
openaire +2 more sources