Results 41 to 50 of about 1,422,910 (361)

Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression [PDF]

, 2015
In a wide variety of bacterial restriction–modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon.
Kneale, G. G., Mcgeehan, J. E., Shevtsov, M. B., Streeter, S. D., Swiderska, A., Thresh, S.-J.   +5 more
core   +2 more sources

Molecular Recognition [PDF]

ChemPhysChem, 2021
Tiddo Jonathan Mooibroek, Steve Scheiner, Hennie Valkenier   +2 more
openaire   +4 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
Aghnoum, Antonovics, Arabidopsis Genome Initiative, Baxter, Bolton, Brunner, Chen, de Jonge, de Jonge, de Wit, Dean, Dong, Elmore, Fan, Fradin, Fry, Gilroy, Gladieux, Haas, Hacquard, Jafary, Jeuken, Jones, Jupe, Jupe, Kang, Karasov, Kaschani, King, Kombrink, Lapin, Lee, Levesque, Lozano-Torres, Ma, Maekawa, Meyers, Mondragon-Palomino, Monosi, Morris, Mueller, Niks, Palloix, Pavan, Pedersen, Porter, Qutob, Raffaele, Raffaele, Raffaele, Rice Genome Project, Rouxel, Ruan, Saunders, Schulze-Lefert, Schweizer, Segretin, Shabab, Shan, Shen, Shindo, Spanu, Stam, Stassen, Stassen, Stirnweis, Stukenbrock, Stukenbrock, Stuttmann, Sweigard, Sørensen, Tian, Tosa, Uma, van Schie, Vega-Arreguín, Vogel, Wawra, Win, Wulff, Zellerhoff, Zhang, Zheng, Zipfel   +83 more
core   +5 more sources

Radically enhanced molecular recognition

Nature Chemistry, 2009
The tendency for viologen radical cations to dimerize has been harnessed to establish a recognition motif based on their ability to form extremely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox state.
Trabolsi, Ali, Khashab, Niveen, Fahrenbach, Albert C., Friedman, Douglas C., Colvin, Michael T., Cotí, Karla K., Benítez, Diego, Tkatchouk, Ekaterina, Olsen, John-Carl, Belowich, Matthew E., Carmielli, Raanan, Khatib, Hussam A., Goddard, William A., III, Wasielewski, Michael R., Stoddart, J. Fraser   +14 more
openaire   +3 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Application of Capillary Electrophoresis with Laser-Induced Fluorescence to Immunoassays and Enzyme Assays

Molecules, 2019
Capillary electrophoresis using laser-induced fluorescence detection (CE-LIF) is one of the most sensitive separation tools among electrical separation methods.
Binh Thanh Nguyen, Min-Jung Kang
doaj   +1 more source

Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents

Biomolecules, 2020
VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent.
Da Li, Jun Ren, Fangling Ji, Qiang Peng, Hu Teng, Lingyun Jia   +5 more
doaj   +1 more source

Influence of correlations on molecular recognition

, 2008
The influence of the patchiness and correlations in the distribution of hydrophobic and polar residues at the interface between two rigid biomolecules on their recognition ability is investigated in idealised coarse-grained lattice models.
B. Alberts, E. Fischer, Friederike Schmid, Hans Behringer, J. Janin, K. Sneppen, M. B. Jackson, M. Delaage, S. Wodak, T. A. Larsen   +9 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source