Results 71 to 80 of about 5,894,644 (362)

Complexation of 2,6-helic[6]arene and its derivatives with 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid–base controllable complexation

Beilstein Journal of Organic Chemistry, 2019
2,6-Helic[6]arene and its derivatives were synthesized, and their complexation with 1,1′-dimethyl-4,4′-bipyridinium and protonated 4,4'-bipyridinium salts were investigated in detail. It was found that the helic[6]arene and its derivatives could all form
Jing Li, Qiang Shi, Ying Han, Chuan-Feng Chen   +3 more
doaj   +1 more source

Facile and Controllable Fabrication of Protein-Only Nanoparticles through Photo-Induced Crosslinking of Albumin and Their Application as DOX Carriers

Nanomaterials, 2019
Protein-based nanoparticles, as an alternative to conventional polymer-based nanoparticles, offer great advantages in biomedical applications owing to their functional and biocompatible characteristics.
Xiangyu Long, Jun Ren, Chao Zhang, Fangling Ji, Lingyun Jia   +4 more
doaj   +1 more source

Molecular Recognition

, 2015
Explanation of the concept of molecular ...
openaire   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Circularly polarized luminescence with high dissymmetry factors for achiral organic molecules in solutions

Nature Communications
Circularly polarized luminescence (CPL) in solution offers several advantages. However, it remains challenging for organic molecules to achieve circularly polarized luminescence with high dissymmetry factor (g lum) in solution. Herein, a general strategy
Ming-Jun Ji, Wen-Long Zhao, Meng Li, Chuan-Feng Chen   +3 more
doaj   +1 more source

MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

Molecular Oncology, 2019
SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I.
Dong‐Kyu Chae, Jinyoung Park, Moonsoo Cho, Eunmi Ban, Mihue Jang, Young Sook Yoo, Eunice EunKyeong Kim, Ja‐Hyun Baik, Eun Joo Song   +8 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

OLIGOSACCHARIDES AND MOLECULAR RECOGNITION [PDF]

, 2014
Carbohydrates have been established as the most abundant ? and arguably the most structural diverse ? organic molecules found in nature. They are chiral molecules readily available in nature in a variety of diastereomeric forms. Their conformational rigidity provides a well defined three-dimensional spatial arrangement of substituents with various ...
openaire   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Allosteric Antagonism of the A_2A Adenosine Receptor by a Series of Bitopic Ligands

Cells, 2020
Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A2A adenosine receptor (A2AAR) ligand classes were reported as pharmacological tools, their receptor binding and ...
Zhan-Guo Gao, Kiran S. Toti, Ryan Campbell, R. Rama Suresh, Huijun Yang, Kenneth A. Jacobson   +5 more
doaj   +1 more source