Results 81 to 90 of about 31,759,038 (276)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Flavor Changes Through the Fermentation Process of Longmen Rice Vinegar

Separations
The flavor profile of Longmen rice vinegar directly influences consumer purchase intention, and understanding its variation during fermentation is crucial for final product quality control.
Yibo Bai, Rui Li, Liman Zheng, Yu Zhang, Huanlu Song, Jing Liu, Weining Huo, Wen Nie, Suyan Wan   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I) [PDF]

, 2008
Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS). In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST) in comparison to an age and gender ...
Lauchart, Meike, Michael Valet, Magerl, Walter, Antje Beyer, Kaufhold, Wibke, Volker Huge, Förderreuther, Stefanie, Valet, Michael, Meike Lauchart, Beyer, Antje, Shahnaz Christina Azad, Huge, Volker, Stefanie Förderreuther, Azad, Shahnaz Christina, Wibke Kaufhold, Walter Magerl, Huge Volker, Kaufhold Wibke, Magerl Walter, Lauchart Meike, Beyer Antje, Förderreuther Stefanie, Valet Michael, Azad Shahnaz Christina   +23 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

International Journal of Molecular Science 2019 Best Paper Award

, 2019
The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics, and chemistry that have been published in the ...
International Journal of Molecular Science Editorial Office International Journal of Molecular Science Editorial Office
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

International Journal of Molecular Science Best Paper Award 2014

, 2014
International Journal of Molecular Science is instituting an annual award to recognize outstanding papers in the area of chemistry, molecular physics and molecular biology published in International Journal of Molecular Science.
Ian A. Nicholls (1617262), Stephen A. Bustin (16654086), Michael Iba (16669584), Bustin, Stephen A.,, Iba, Michael,, Stephen Bustin, Nicholls, Ian A.,, Ian Nicholls, Michael Iba   +8 more
core   +1 more source