Results 111 to 120 of about 2,703,182 (313)

Systems biology in inflammatory bowel diseases [PDF]

, 2014
Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Dense cores in the dark cloud complex LDN1188

, 2013
We present a molecular line emission study of the LDN1188 dark cloud complex located in Cepheus. In this work we focused on the densest parts of the cloud and on the close neighbourhood of infrared point sources.
Kiss, Cs., Kun, M., Könyves, V., Moór, A., Nikolić, S., Verebélyi, E., Ábrahám, P.   +6 more
core   +1 more source

Objective sequence-based subfamily classifications of mouse homeodomains reflect their in vitro DNA-binding preferences [PDF]

, 2010
Classifying proteins into subgroups with similar molecular function on the basis of sequence is an important step in deriving reliable functional annotations computationally.
Addou, Altschul, Altschul, Andreeva, Andrei L. Turinsky, Andrew R. Gehrke, Badis, Benos, Berger, Berger, Berman, Brohee, Brown, Brown, Brown, Bulyk, Bulyk, Carbon, Donald, Dudley, Edgar, Enright, Enright, Finn, Furukubo-Tokunaga, Garcia-Fernandez, Gascuel, Gwenael Badis, Harbison, Hayashi, Hoffmann, Holland, Hunter, Itzkovitz, Jennifer Tsai, Katoh, Kawaji, Krishnamurthy, Lee, Lees, Li, Li, Luscombe, Mackay, Man, Martha L. Bulyk, Matys, Meila, Michael F. Berger, Miguel A. Santos, Mukherjee, Ochagavia, Peregrin-Alvarez, Ravasi, Remm, Scott, Serene Ong, Shaheynoor Talukder, Shoshana J. Wodak, Sjolander, Storm, Takatori, Thompson, Timothy R. Hughes, Tsai, van Dongen, Vlasblom, Vlieghe, Weston, Wicker, Wilson, Zhong, Zmasek   +72 more
core   +3 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The adsorption of adsorbable organic halide onto biological solids : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Technology in Environmental Engineering [PDF]

, 1994
Chlorinated organic molecules may be removed from wastewaters by adsorption onto the biomass present in biological treatment systems. This study assessed the adsorption onto biological solids of Adsorbable Organic Halide (AOX) from two New Zealand kraft ...
Gapes, Daniel James
core  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source