Results 211 to 220 of about 2,823,273 (337)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Functional characterization of antennae-enriched chemosensory protein 4 in emerald ash borer, Agrilus planipennis. [PDF]

PeerJ
Li R, Wang Z, Yang F, Qiao G, Tu J, Sun A, Wang S.   +6 more
europepmc   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Sequence Data Analysis Guidebook. Methods in Molecular Biology, Volume 70. Edited by Simon R. Swindell. Humana Press, 1997. 324 pages. Price $69.50. ISBN 0 89603 358 9. [PDF]

, 1997
Andrew Coulson
openalex   +1 more source

Molecular epidemiology and genomic features of Bordetella pertussis in Tianjin, China, 2023. [PDF]

BMC Microbiol
Lu X, Li W, Chen X, Zhang W, Yu A, Liu G, Zheng B, Gao X, Liu Y, Li X.   +9 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Prevalence and molecular basis of resistance to echinocandins among clinical Candida glabrata isolates in Guangdong province, China. [PDF]

BMC Microbiol
Lin W, Peng Y, Xiang B, Fang J, Ye J, Guo P.   +5 more
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Molecular cloning and functional expression of Xenopus laevis oocyte ATP-activated P2X4 channels1The nucleotide sequence data reported in this paper have been deposited in the GenBank database under accession Nos. AF308148 (xP2X4a), AF308149 (xP2X4b), AF308150 (xP2X4c), AF308151 (xP2X4d), AF308152 (xP2X4e) and AF308153 (xP2X4f).1

, 2001
Peter F. Juranka, A. Pejmun Haghighi, Tara Gaertner, Ellis Cooper, Catherine E. Morris   +4 more
openalex   +1 more source

Bridging artificial intelligence and biological sciences: a comprehensive review of large language models in bioinformatics. [PDF]

Brief Bioinform
Lin A, Ye J, Qi C, Zhu L, Mou W, Gan W, Zeng D, Tang B, Xiao M, Chu G, Peng S, Wong HZH, Zhang L, Zhang H, Deng X, Li K, Zhang J, Jiang A, Li Z, Luo P.   +19 more
europepmc   +1 more source