Results 221 to 230 of about 2,847,669 (316)

Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety. [PDF]

Sci Rep
Huertas T, Millán D, Fonseca-Benítez AV, Guevara-Pulido J.   +3 more
europepmc   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

The complete chloroplast genome of oriental false hawksbeard <i>Youngia japonica</i> (Asteraceae, tribe Cichorieae). [PDF]

Mitochondrial DNA B Resour
Kim HT, Kim JS.
europepmc   +1 more source

Molecular cloning and functional expression of Xenopus laevis oocyte ATP-activated P2X4 channels1The nucleotide sequence data reported in this paper have been deposited in the GenBank database under accession Nos. AF308148 (xP2X4a), AF308149 (xP2X4b), AF308150 (xP2X4c), AF308151 (xP2X4d), AF308152 (xP2X4e) and AF308153 (xP2X4f).1

, 2001
Peter F. Juranka, A. Pejmun Haghighi, Tara Gaertner, Ellis Cooper, Catherine E. Morris   +4 more
openalex   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

MEN: leveraging explainable multimodal encoding network for precision prediction of CYP450 inhibitors. [PDF]

Sci Rep
Atwereboannah AA, Wu WP, Al-Antari MA, Yussif SB, Ejiyi CJ, Tenagyei EK, Kissanga GB, Emmanuel GSA, Gu YH, Ahene E.   +9 more
europepmc   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Foundation models in plant molecular biology: advances, challenges, and future directions. [PDF]

Front Plant Sci
Xu F, Wu T, Cheng Q, Wang X, Yan J.
europepmc   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

The UniProt website API: facilitating programmatic access to protein knowledge. [PDF]

Nucleic Acids Res
Ahmad S, Jose da Costa Gonzales L, Bowler-Barnett EH, Rice DL, Kim M, Wijerathne S, Luciani A, Kandasaamy S, Luo J, Watkins X, Turner E, Martin MJ, UniProt Consortium .   +12 more
europepmc   +1 more source