Results 221 to 230 of about 4,241,168 (373)

Molecular phylogeny of Pinanga (Palmae) based on internal transcribed spacers (ITS) sequence data

, 2007
Joko Ridho Witono, Katsuhiko Kondo
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Machine learning-guided optimization of triple agonist peptide therapeutics for metabolic disease. [PDF]

Front Bioinform
Wong A, Guduri S, Chen T, Patel K.
europepmc   +1 more source

A molecular phylogenetic study of temperate grasses in Poeae chloroplast group 1 (Poaceae: Pooideae: Poeae) based on nuclear ribosomal and plastid DNA sequence data

, 2017
Jeffery M. Saarela, Roger D. Bull, Michel J. Paradis, Sharon N. Ebata, Paul M. Peterson, Robert J. Soreng, Beata Paszko   +6 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Preliminary investigation of heat shock protein 90 gene diversity in Echinococcus granulosus sensu lato: a potential nuclear marker for species identification. [PDF]

Parasitol Res
Lamia Z, Myriam OM, Raja CB, Ines K, Umhang G, Hedi AM, Taoufik S, Marwa M, Lassaad S, Boué F, Hamouda B, Selim M.   +11 more
europepmc   +1 more source

Deciphering molecular origin and functional impact of structural variation in maize through genome sequences comparison and integrative analysis of genetic variation, transcriptome and phenotype data

, 2018
Johann Joets, Sylvie Coursol, Olivier Turc, Llorenç Cabrera‐Bosquet, Marie-Laure Magniette Martin-Magniette, Silvio Salvi, Anthony Venon, Sandrine Chaignon, Jérôme Laplaige, Ghislaine Gendrot, Carine Palaffre, Stéphanie Castel, Stéphanie Pateyron, Véronique Brunaud, Ludivine Soubigou‐Taconnat, Fabrice Dumas, William Marande, Agnès Rousselet, Harry Belcram, Alain Charcosset, François Tardieu, Claude Welcker, Peter Rogowsky, Clémentine Vitte   +23 more
openalex   +1 more source

FIGURE 5 in Two new Docosia Winnertz species (Diptera: Mycetophilidae) from Transcaucasia, with DNA sequence data and updated molecular phylogeny

Kurina, Olavi, Burdíková, Nikola, Ševčík, Jan   +2 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Designing novel peptides with amyloid-<i>β</i> binding and clearance potential using BiLSTM and molecular dynamics. [PDF]

Front Artif Intell
Yata VK, Das OP, Dansana J, Gadtya A, Meher BR, Bukke SPN, Kolliputi N.   +6 more
europepmc   +1 more source