Results 91 to 100 of about 4,733,523 (302)

Protein folding on the ribosome studied using NMR spectroscopy [PDF]

, 2013
NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
Christodoulou, J, Christodoulou, John, Launay, H, Launay, Hélène, Cabrita, Lisa D., Cabrita, L.D., Launay, H., Waudby, CA, Cabrita, LD, Waudby, Christopher A.   +9 more
core   +1 more source

Two-dimensional infrared spectroscopic study of cytochrome c peroxidase activity in deep eutectic solvent

Structural Dynamics, 2019
Deep eutectic solvents (DESs) prepared by mixing hydrogen-bond donor and acceptor molecules have been found to be of use in several applications. Recently, it was shown that DESs can enhance the peroxidation activity of cytochrome c.
Koji Osawa, Dorota Kossowska, Kwanghee Park, Kyungwon Kwak, Minhaeng Cho   +4 more
doaj   +1 more source

Deep tissue space-gated microscopy via acousto-optic interaction

Nature Communications, 2020
In ideal diffraction-limited optical microscopy imaging depth is limited by the multiply scattered wave. Here, the authors present a space gating method, based on an acoustic focus in the object plane and reconstruction using only the acousto-optically ...
Mooseok Jang, Hakseok Ko, Jin Hee Hong, Won Kyu Lee, Jae-Seung Lee, Wonshik Choi   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Machine-learning enhanced simulations predict graphene is microscopically hydrophobic and not wetting transparent

Nature Communications
The interaction between graphene and water is fundamental to applications ranging from filtration to nano-electronics, yet the intrinsic wettability of graphene remains a subject of longstanding debate.
Dianwei Hou, Yevhen Horbatenko, Stefan Ringe, Minhaeng Cho   +3 more
doaj   +1 more source

Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary ...
Kamal Saba, Niharika Rajnala, Pandichelvam Veeraiah, Vivek Tiwari, Rohit K. Rana, Subhash C. Lakhotia, Anant B. Patel   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Label-free haemogram using wavelength modulated Raman spectroscopy for identifying immune-cell subset [PDF]

, 2014
The authors thank the UK EPSRC the CR-UK/EPSRC/MRC/DoH (England) imaging Program and the European Union project FAMOS (FP7 ICT, contract no. 317744) for funding, K.D. is a Royal Society-Wolfson Merit Award Holder.Leucocytes in the blood of mammals form a
Bavishna B. Praveen, Powis, S.J., Campbell, E.C., Ashok, P.C., Praveen, B.B., Simon J. Powis, Dholakia, K., Praveen C. Ashok, Elaine C. Campbell, Kishan Dholakia   +9 more
core   +1 more source

Stereoelectronic and hydrogen-bonding effects on hydroxyproline conformation

Communications Chemistry
Collagen’s structural integrity and biological function derive from its characteristic triple helix, governed by a unique amino acid sequence containing the rare residue (2S,4R)-hydroxyproline (4R-Hyp).
Fumiki Matsumura, Pablo Gómez Argudo, Mischa Bonn, Giulia Giubertoni, Johannes Hunger   +4 more
doaj   +1 more source

High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering

Nature Communications, 2017
Optical imaging deep in biological tissue is difficult due to multiple scattering and specimen induced aberrations of both the incident and reflected light. Here, Kang et al.
Sungsam Kang, Pilsung Kang, Seungwon Jeong, Yongwoo Kwon, Taeseok D. Yang, Jin Hee Hong, Moonseok Kim, Kyung–Deok Song, Jin Hyoung Park, Jun Ho Lee, Myoung Joon Kim, Ki Hean Kim, Wonshik Choi   +12 more
doaj   +1 more source