Results 81 to 90 of about 4,733,523 (302)

Isoniazid–Saccharin Salts: Synthesis, Structural Aspects, Thermal Properties and Spectroscopic Characterization

Molecules
This investigation focused on isoniazid (INH)—saccharin (SAC) salts. One hydrate and one anhydrous INH-SAC salt form were synthesized and characterized spectroscopically by Raman and infrared spectroscopy.
Rezvan Mohammadi, Ayberk Yilmaz, Nihal Sarier, José António Paixão, Gulce Ogruc Ildiz, Rui Fausto   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Reactivity mapping of nanoscale defect chemistry under electrochemical reaction conditions

Nature Communications, 2019
Identifying reacting species locally with nanometer precision is a major challenge in electrochemical surface science. Using operando Raman nanoscopy, authors image the reversible, concurrent formation of nanometer-spatially separated Au2O3 and Au2O ...
Jonas H. K. Pfisterer, Masoud Baghernejad, Giovanni Giuzio, Katrin F. Domke   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Semiclassical Dynamics: A Viable Route to Molecular Spectroscopy [PDF]

, 2017
Reliable molecular spectroscopy simulations require an accurate quantum description of nuclear motion. Since purely quantum mechanical approaches are not affordable when dealing with high dimensional systems, an alternative path must be followed ...
F. Gabas, R. Conte, G. Di Liberto, M. Ceotto   +3 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Two-Dimensional Vibrational Spectroscopy of Rotaxane-Based Molecular Machines

, 2009
It has recently become possible to synthesize mechanical devices the size of a single molecule. Although it is tempting to regard such molecular machines as nanoscale versions of their macroscopic analogs, many notions from macroscopic mechanics no ...
S. Woutersen, E. R. Kay, Panman, Matthijs R., Buma, W.J., Bakker, Bert H., B. H. Bakker, M. R. Panman, Woutersen, Sander, Woutersen, S., Brouwer, Albert M., W. J. Buma, Bakker, Bert H, Brouwer, A.M., Leigh, David A., P. Bodis, Mateo-Alonso, Aurelio, Panman, M.R., Kay, Euan R., Buma, Wybren Jan, Bodis, P., Kay, Euan R, A. M. Brouwer, A. Mateo Alonso, Bakker, B.H., Prato, M., Bodis, Pavol, Brouwer, Albert M, D. A. Leigh, Buma, Wybren J, Kay, E.R., Panman, Matthijs R, Leigh, D.A., Brouwer, A.M.; id_orcid, PRATO, MAURIZIO, Mateo-Alonso, A., Leigh, David A; id_orcid   +35 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source