Results 81 to 90 of about 4,989,468 (303)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Interpretable Deep Supramolecular Language Modeling for Cocrystal Design: PCA-Augmented DeepCocrystal Screening of Picolinamide, Nicotinamide, and Isonicotinamide Systems

Molecules
Cocrystallization is an effective strategy for modifying the physicochemical properties of active pharmaceutical ingredients (APIs), yet rational coformer selection remains challenging. In this work, we propose an interpretable extension of DeepCocrystal
Bahadır Bozkurt, Ayberk Yilmaz, Gulce Ogruc Ildiz, Rui Fausto   +3 more
doaj   +1 more source

Reactivity mapping of nanoscale defect chemistry under electrochemical reaction conditions

Nature Communications, 2019
Identifying reacting species locally with nanometer precision is a major challenge in electrochemical surface science. Using operando Raman nanoscopy, authors image the reversible, concurrent formation of nanometer-spatially separated Au2O3 and Au2O ...
Jonas H. K. Pfisterer, Masoud Baghernejad, Giovanni Giuzio, Katrin F. Domke   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Protein folding on the ribosome studied using NMR spectroscopy [PDF]

, 2013
NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
Christodoulou, J, Christodoulou, John, Launay, H, Cabrita, L.D., Launay, H., Waudby, CA, Cabrita, LD, Waudby, Christopher A.   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PHOTONICS-BASED TERAHERTZ SOURCES FOR MOLECULAR SPECTROSCOPY

\begin{wrapfigure}{r}{0pt} \includegraphics[scale=0.3]{Spectrum.eps} \end{wrapfigure} Since twenty years photonics-based terahertz (THz) sources have made great progress.
Lampin, Jean-François
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Semiclassical Molecular Dynamics as a useful tool for Nuclear Spectroscopy

, 2022
Semiclassical Initial Value Representaiton (SCIVR) molecular dynamics has been known since a long time to be able to calculate accurately vibrational power spectra of small, isolated molecules with inclusion of quantum effects, such as zero-point ...
Giacomo Mandelli, Chiara Aieta, Alessandro Rognoni, Michele Gandolfi, Riccardo Conte, Fabio Gabas, Michele Ceotto, Marco Cazzaniga, Giacomo Botti, Davide Moscato, Cecilia Lanzi, Gianluca Bertaina   +11 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source