Results 61 to 70 of about 208,473 (269)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Timing molecular motion and production with a synthetic transcriptional clock [PDF]

, 2011
The realization of artificial biochemical reaction networks with unique functionality is one of the main challenges for the development of synthetic biology. Due to the reduced number of components, biochemical circuits constructed in vitro promise to be
Atkinson, Babendure, Buchler, Chamberlin, Danino, Del Vecchio, Dittmer, E. Franco, E. Friedrichs, E. Winfree, Elowitz, F. C. Simmel, Faeder, Ferrari, Fung, Grate, Green, Ishikawa, J. Kim, Kim, Kim, Kurin-Cs  rgei, Liedl, Lima, Luisi, McCarrey, Muller, Panyutin, R. Jungmann, R. Murray, Simpson, Stricker, Tigges, Yurke, Zuker   +34 more
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Thermodynamics and Kinetics of Guest-Induced Switching between “Basket Handle” Porphyrin Isomers

Molecules, 2014
The synthesis and switching properties of two “basket handle” porphyrin isomers is described. The cis-oriented meso-phenyl groups of these porphyrins are linked at their ortho-positons via benzocrown-ether-based spacers, which as a result of slow ...
Alexander B. C. Deutman, Tim Woltinge, Jan M. M. Smits, René De Gelder, Johannes A. A. W. Elemans, Roeland J. M. Nolte, Alan E. Rowan   +6 more
doaj   +1 more source

Indane Based Molecular Motors: UV-Switching Increases Number of Isomers

Molecules, 2022
We describe azophenylindane based molecular motors (aphin-switches) which have two different rotamers of trans-configuration and four different rotamers of cis-configuration.
Valeriy P. Shendrikov, Anna S. Alekseeva, Erik F. Kot, Konstantin S. Mineev, Daria S. Tretiakova, Abdulilah Ece, Ivan A. Boldyrev   +6 more
doaj   +1 more source

Molecular dynamics simulations of oxide memory resistors (memristors)

, 2010
Reversible bipolar nano-switches that can be set and read electronically in a solid-state two-terminal device are very promising for applications. We have performed molecular-dynamics simulations that mimic systems with oxygen vacancies interacting via ...
A M Bratkovsky, A S Alexandrov, Alexandrov A S, Dearnaley G, Fujii T, Kreynina G S, Kreynina G S, Meis C, Oxley D P, R Stanley Williams, S E Savel’ev, Stafeev V I, Strachan J P, Strachan J P, Xia Q, Yang J J, Yang J J   +16 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A Molecular-Rotor Device for Nonvolatile High-Density Memory Applications [PDF]

, 2010
A novel memory device based on an electrically driven molecular rotor was fabricated and demonstrated to have bistable switching effects. The device showed an on/off ratio of approximately 10^4, a read window of about 2.5 V, and retention performance of
Benitez, Diego, Goddard, William A., III, Kabehie, Sanaz, Stieg, Adam Z., Tkatchouk, Ekaterina, Wang, Kang L., Xue, Mei, Zink, Jeffrey I.   +7 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source