Results 91 to 100 of about 2,123,606 (402)
Systemic Therapy in Endometrial Cancer: Recent Advances. [PDF]
, 2013 Endometrial cancer is a chemosensitive disease. Studies have established a clear benefit of chemotherapy in advanced stages and trials are ongoing to define its role in early stages as well.
Bhise, R +5 more
core +1 more source
Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]
, 2019 The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T. +3 more
core +1 more source
Inferring diagnostic and prognostic gene expression signatures across WHO glioma classifications: A network-based approach [PDF]
arXiv, 2023 Tumor heterogeneity is a challenge to designing effective and targeted therapies. Glioma-type identification depends on specific molecular and histological features, which are defined by the official WHO classification CNS. These guidelines are constantly updated to support the diagnosis process, which affects all the successive clinical decisions.
arxiv
The efficiency of multi-target drugs: the network approach might help drug design [PDF]
Trends in Pharmacological Sciences 26, 178-182 (2005), 2004 Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increase appreciably during the past decade. Network models suggest that partial inhibition of a surprisingly small number of targets can be more efficient than the complete ...
arxiv +1 more source
Molecular CancerBackground Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RNAs (circRNAs) have emerged as key regulators of the metastasis of various cancers.
Xiang Pan +10 more
doaj +1 more source
Cold and hot tumors: from molecular mechanisms to targeted therapy
Signal Transduction and Targeted TherapyImmunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which has shown notable clinical benefits across various tumor types.
Bo Wu +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Metastatic melanoma-A review of current and future perspective [PDF]
arXiv, 2020 Metastatic Melanoma, the fifth most common cancer in the western countries and the most common malignancy diagnosed in United States present itself as the most lethal treatment resistant cancer worldwide. In addition to the reactive oxygen species(ROS), mutations in the genes encoding receptors and non-receptor tyrosine/serene/threonine protein kinases
arxiv
Biological control networks suggest the use of biomimetic sets for combinatorial therapies [PDF]
PLoS ONE 7(1): e29374 (2012), 2010 Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these "many-to-many" combinatorial control systems are poorly understood. Here we analyze distinct cellular networks (transcription factors, microRNAs, and protein kinases) and a drug-target network.
arxiv +1 more source
Frontiers in Immunology, 2021 The loss of inhibitor of differentiation-2 (ID2) could lead to the development of colitis in mice, supplementation with exogenous ID2 protein might be a potential strategy to ameliorate colitis.
Jie Ren +11 more
doaj +1 more source