Results 191 to 200 of about 6,883,814 (290)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A Review of the Current Clinical Aspects of Sjögren's Disease: Geographical Difference, Classification/Diagnostic Criteria, Recent Advancements in Diagnostic Methods, and Molecular Targeted Therapy. [PDF]

J Clin Med
Horai Y, Kurushima S, Shimizu T, Nakamura H, Kawakami A.   +4 more
europepmc   +1 more source

Advances in the Treatment of Spinal Metastasis: Commentary on "Spinal Metastases and the Evolving Role of Molecular Targeted Therapy, Chemotherapy, and Immunotherapy". [PDF]

Neurospine, 2022
Bergin S, Than KD.
europepmc   +1 more source

Molecular target therapy for malignant tumor 1) The molecular target therapy.

Nihon Naika Gakkai Zasshi, 2005
openaire   +2 more sources

Pathology confronts molecular targeted therapies [PDF]

Nature Clinical Practice Oncology, 2006
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Innovative Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with Various Pathway Signaling. [PDF]

Int J Mol Cell Med
Haki M, Bayat R.
europepmc   +1 more source

A Unique Case of Intracranial Amelanotic Melanoma with BRAF V600E Mutation Successfully Treated via Molecular-targeted Therapy. [PDF]

NMC Case Rep J, 2023
Fujita J, Tomita Y, Ichimura K, Yamasaki R, Nishigaki S, Nitta Y, Inoue Y, Sotome Y, Kidani N, Muraoka K, Hirotsune N, Nishino S.   +11 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Molecular Targeted Therapy Plus PD-(L)1 with or without TACE in Unresectable Hepatocellular Carcinoma: A Retrospective Study. [PDF]

Immunotargets Ther
Liu J, Wang Y, Cui L, Nie Y, Li C, Tan W, Li Y, Bai Y, Wan T, Hu B, Liu Z, Hu M, Wang M, Duan F.   +13 more
europepmc   +1 more source