Results 281 to 290 of about 631,529 (311)
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2017
Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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[Molecular targeted therapies].
Nihon rinsho. Japanese journal of clinical medicine, 2010Current treatment paradigms in cancer patients are shifting from cytotoxic chemotherapies alone to single-agent and combination biological and targeted therapies. Targeted therapies are entering standard treatment paradigms. As patient responses to targeted therapies vary, predictive biomarkers will be an important tool of a patient's diagnostic workup
Hideharu, Kimura, Kazuto, Nishio
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Molecular targeted therapy for hepatocellular carcinoma
Journal of Gastroenterology, 2009A majority of patients with HCC present with advanced disease and are not candidates for liver transplantation, surgical resection, or regional therapy. Systemic cytotoxic chemotherapy agents are minimally effective, can have significant toxicity, and have not been shown to improve patient survival. Hepatocellular carcinomas are inherently chemotherapy-
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Targeted molecular therapy for malignant gliomas
Current Treatment Options in Oncology, 2004Advances in our understanding of the molecular changes and resultant cellular effects in malignant glioma are expanding the opportunities for novel targeted therapies. At present, chemotherapy and radiation followed by chemotherapy with nonselective cytotoxic agents is emerging as a standard treatment option for patients with malignant glioma ...
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Molecular Targets and Therapies for Ampullary Cancer
Journal of the National Comprehensive Cancer NetworkAmpullary carcinomas are rare but increasing in incidence. Ampullary cancers have molecular alterations that guide choice of therapy, particularly in nonresectable cases. These alterations can be more common by subtype (intestinal, pancreaticobiliary, or mixed), and next-generation sequencing is recommended for all patients who cannot undergo surgery ...
Monica Arun, Patel +5 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 2003
This article reviews the concept of molecular-targeted therapy and the current development status of molecular-targeted agents for lung cancer. Epidermal growth factor receptor inhibitors have shown promising antitumor activity against cisplatin-resistant non-small cell lung cancer in phase II trials. Appropriate clinical evaluation of these agents and
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This article reviews the concept of molecular-targeted therapy and the current development status of molecular-targeted agents for lung cancer. Epidermal growth factor receptor inhibitors have shown promising antitumor activity against cisplatin-resistant non-small cell lung cancer in phase II trials. Appropriate clinical evaluation of these agents and
openaire +1 more source
Nanomaterials Enhance the Immunomodulatory Effect of Molecular Targeted Therapy
International Journal of Nanomedicine, 2021Zhongmin Li, Xuedong Fang, Zhenbo Shu
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