Results 261 to 270 of about 631,529 (311)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

[Advances of Molecular Targeted Therapy in EGFR-mutated Squamous Cell Lung Cancer]. [PDF]

Zhongguo Fei Ai Za Zhi
Xiong B, Ke W, Jiang W.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma: A work in progress. [PDF]

Neurooncol Adv
Yankelevich M, Zaky W, Lafay-Cousin L, Osorio D, Adamski J, Kordes U, Finlay JL, Prados M, Mueller S.   +8 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

New strategy for monitoring targeted therapy: molecular imaging

International Journal of Nanomedicine, 2013
Fei-Fei Teng, Xue Meng, Xin-Dong Sun, Jin-Ming YuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, Jinan, People's Republic of ChinaAbstract: Targeted therapy is becoming an increasingly important ...
Jinming Yu, Xindong Sun, Feifei Teng
exaly   +1 more source

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Molecular targets in cancer therapy

Expert Review of Anticancer Therapy, 2013
24th EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics' 6-9 November 2012, Dublin, Ireland The EORTC-NCI-AACR Symposium is an annual meeting, jointly hosted by the European Organization for Research and Treatment of Cancer, the US National Cancer Institute and the American Association for Cancer Research, to encourage exchange of ...
Shivaani, Kummar, James H, Doroshow
openaire   +2 more sources

Molecular targets of gene therapy

The Annals of Thoracic Surgery, 1999
Ischemic reperfused heart represents a potential target for gene therapy because gene transfer can represent an alternate pharmacological approach to protect the heart from cellular injury. Gene therapy may be particularly useful to deal with previously unapproachable problems.
D K, Das, R M, Engelman, N, Maulik, J A, Rousou, J E, Flack, D W, Deaton   +5 more
openaire   +2 more sources

Molecular Targets for Papillomavirus Therapy

Current Drug Target -Infectious Disorders, 2003
Papillomaviruses are infectious agents for human and animal epithelial tissue, and nearly 100 distinct human types (HPVs) have been identified. When these viruses infect cutaneous or mucosal skin they can initially cause clinical warts or persistent infection with little or no visible manifestations.
V G, Wilson, G, Rosas-Acosta
openaire   +2 more sources