Results 251 to 260 of about 6,883,814 (290)
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Targeted Molecular Therapy in Melanoma
Seminars in Cutaneous Medicine and Surgery, 2010Immunotherapy and chemotherapy benefit few patients with metastatic melanoma, and even fewer experience durable survival benefit. These poor results may come from treating all melanomas as though they are biologically homogeneous. Recently, it has been shown that targeting specific activated tyrosine kinases (oncogenes) can have striking clinical ...
Igor, Puzanov, Keith T, Flaherty
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Molecular Targets of Antiviral Therapy
New England Journal of Medicine, 1989THE development of specific antiviral drugs that are minimally toxic to normal cells has ushered in a new era of antiviral therapy.
Jeffrey S. Flier +2 more
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Molecular Targets and Targeted Therapies for Malignant Mesothelioma
Current Medicinal Chemistry, 2008Malignant mesothelioma is a highly invasive tumor originating from the mesothelial linings of the pleura, peritoneum and pericardium. It is seldom amenable to surgical intervention and poorly responsive to radiotherapy, leaving chemotherapy as the main therapeutic option for most patients. The development of effective drug regimens against mesothelioma
PALUMBO, CAMILLA +3 more
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Molecular targets in cancer therapy
Seminars in Oncology Nursing, 2003To review selected pharmacologic agents that target key cellular processes along with their mechanisms of action and adverse events. Nursing implications including what patients and families need to know, administration issues, and management of common toxicities will be reviewed.Research articles, clinical trials, abstracts, and book chapters ...
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Principles of Molecular Targeting for Radionuclide Therapy
2022Molecular targeting requires assessing several factors that come into play such as the location of the target, the choice of radionuclide, the inertness of the bifunctional chelate and stability of the covalently bound halogens, matching the residence time in the tumor with the physical half-life of the radionuclide, the scale and scope of the disease,
Francesco Bartoli +4 more
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2019
The treatment of advanced thyroid cancer has developed with increased understanding of the molecular basis of the disease. Alongside this targeted therapies have been developed, and there is evidence of efficacy for multikinase inhibitors in improving progression-free survival in this population of patients.
Arabella Hunt, Kate L. Newbold
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The treatment of advanced thyroid cancer has developed with increased understanding of the molecular basis of the disease. Alongside this targeted therapies have been developed, and there is evidence of efficacy for multikinase inhibitors in improving progression-free survival in this population of patients.
Arabella Hunt, Kate L. Newbold
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The Molecular Pathogenesis and Targeted Therapies for Cholangiocarcinoma
Surgical Pathology Clinics, 2022Cholangiocarcinoma (CCA) is a group of malignancies of the bile ducts with high mortality rates and limited treatment options. In the past decades, remarkable efforts have been dedicated toward elucidating the specific molecular signaling pathways and oncogenic loops driving cholangiocarcinogenesis to ultimately develop more effective therapies ...
Nesteene Joy, Param +2 more
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Signaling lipids: Molecular targets for targeted therapies
Current Opinion in Chemical BiologyRecent advances in lipid biology have reshaped our understanding of lipids as dynamic signaling mediators rather than just structural or energy-storage molecules. Over the years, diverse classes of signaling lipids have been identified, and they have been shown to govern key physiological processes through interactions with specific receptors ...
Aakash Chandramouli, Siddhesh S. Kamat
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2017
Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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Defining potential molecular targets for sepsis therapeutics has proven to be a real challenge in translating laboratory findings into effective clinical treatments. A myriad of possible targets have been proposed from preclinical studies but they often have overlapping pathologic functions, can differ depending upon the causative microbial pathogen ...
Andre C. Kalil, Steven M. Opal
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Targeted molecular therapy of malignant gliomas
Current Neurology and Neuroscience Reports, 2005Malignant gliomas are the most common form of primary brain tumors in adults. Despite advances in diagnosis and standard therapies such as surgery, radiation, and chemotherapy, the prognosis remains poor. Recent scientific advances have enhanced our understanding of the biology of gliomas and the role of tyrosine kinase receptors and signal ...
Santosh, Kesari +4 more
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